Stereospecific antiarrhythmic effect of opioid receptor antagonists in myocardial ischaemia

J. Parratt, R. Sitsapesan

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The effects of the stereoisomers of two different antagonists at opioid receptors were examined on the ventricular arrhythmias that result from acute coronary artery ligation in anaesthetized male rats. (-)-Mr 1452 (but not the (+)-isomer, Mr 1453) reduced, in a dose-dependent manner, the number of ventricular ectopic beats and the incidence or duration of both ventricular tachycardia and fibrillation. (-)-WIN 44,441-3 (but not its (+)-isomer, WIN 44,441-2) had a similar protective effect in ischaemia. These results sugest that antagonism of the effects of endogenous opioid peptides at specific receptors results in reduced severity of arrhythmias in myocardial ischaemia.

Original languageEnglish
Pages (from-to)621-622
Number of pages2
JournalBritish Journal of Pharmacology
Volume87
Issue number4
Publication statusPublished - 1986

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Narcotic Antagonists
Myocardial Ischemia
Cardiac Arrhythmias
Stereoisomerism
Ventricular Premature Complexes
Opioid Peptides
Ventricular Fibrillation
Ventricular Tachycardia
Ligation
Coronary Vessels
Ischemia
Incidence
Mr 1452

ASJC Scopus subject areas

  • Pharmacology

Cite this

Stereospecific antiarrhythmic effect of opioid receptor antagonists in myocardial ischaemia. / Parratt, J.; Sitsapesan, R.

In: British Journal of Pharmacology, Vol. 87, No. 4, 1986, p. 621-622.

Research output: Contribution to journalArticle

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