Stereoselective synthesis of a 2,3-disubstituted 5-pyr-rolidinone derivative of quinazolin-4(3H)-one

Mónika Szabó, J. Kökösi, Attila Kovács, Zsolt Böcskei, I. Hermecz

Research output: Contribution to journalArticle

Abstract

Thermal cyclization of acetoacetamide (3), prepared from 2-[1'-(p-methoxyphenylaminoethyl]quinazolin-4(3H)-one (2) and ethyl acetoacetate, resulted in the formation of 2-(5-oxopyrrolidin-2-yl)quinazolin-4(3H)-one (6) with high selectivity in excellent yield. The stereostructure of 6 was investigated by NMR spectroscopy, and determined by X-Ray investigations.

Original languageEnglish
Pages (from-to)2437-2442
Number of pages6
JournalHeterocycles
Volume45
Issue number12
Publication statusPublished - 1997

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Cyclization
Nuclear magnetic resonance spectroscopy
Derivatives
X rays
Magnetic Resonance Spectroscopy
Hot Temperature
X-Rays
ethyl acetoacetate
4-hydroxyquinazoline

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Stereoselective synthesis of a 2,3-disubstituted 5-pyr-rolidinone derivative of quinazolin-4(3H)-one. / Szabó, Mónika; Kökösi, J.; Kovács, Attila; Böcskei, Zsolt; Hermecz, I.

In: Heterocycles, Vol. 45, No. 12, 1997, p. 2437-2442.

Research output: Contribution to journalArticle

Szabó, Mónika ; Kökösi, J. ; Kovács, Attila ; Böcskei, Zsolt ; Hermecz, I. / Stereoselective synthesis of a 2,3-disubstituted 5-pyr-rolidinone derivative of quinazolin-4(3H)-one. In: Heterocycles. 1997 ; Vol. 45, No. 12. pp. 2437-2442.
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