Stereoselective interaction of drug enantiomers with human serum transferrin in capillary zone electrophoresis

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Abstract

Stereoselective interaction of drugs with human serum transferrin in capillary zone electrophoresis is described. The substances passed a pseudo-stationary protein zone applied in a coated capillary and the possible chiral separation of the optical isomers was followed. Drugs with different structures were screened and the enantiomers of bupivacaine, propranolol and promethazine as well as the diastereomers of labetalol were resolved. Racemic mixtures of atenolol and pindolol enantiomers could not be resolved under these conditions.

Original languageEnglish
Pages (from-to)1950-1953
Number of pages4
JournalElectrophoresis
Volume17
Issue number12
DOIs
Publication statusPublished - Dec 1 1996

Keywords

  • Capillary electrophoresis
  • Chiral separation
  • Drugs
  • Proteins
  • Transferrin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

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