Stereoselective interaction of drug enantiomers with human serum transferrin in capillary zone electrophoresis (II)

Martin G. Schmid, Gerald Gübitz, Ferenc Kilár

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Further studies on chiral resolution of drugs with different chemical structures by capillary zone electrophoresis using iron-free human serum transferrin are described. The substances passed a highly concentrated pseudo-stationary protein zone applied in a coated capillary and the possible chiral separation of the optical isomers was followed. Eighteen drugs with different structures were screened, and the enantiomers of clofedanol, buphenine, acebutolol and chlorphenamine were resolved. Several, but not all drugs, showed longer migration times while passing the protein zone, indicating an interaction with transferrin, although chiral resolution was not observed in all cases. The observations provided further information about the properties of the surface interaction sites of transferrin.

Original languageEnglish
Pages (from-to)282-287
Number of pages6
JournalELECTROPHORESIS
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 1 1998

Keywords

  • Capillary electrophoresis
  • Chiral separation
  • Drugs
  • Surface binding site
  • Transferrin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

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