Stereoselective Hydrolase-Catalyzed Processes in Continuous-Flow Mode

Zoltán Boros, Gábor Hornyánszky, József Nagy, L. Poppe

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Citations (Scopus)

Abstract

This chapter demonstrates with a wide range of examples the high potential of continuous-flow techniques for stereoselective biotransformations catalyzed by enzymes, especially hydrolases. Benefits of the various reactor setups are discussed, for example, the continuous flow packed bed reactors can enhance the productivity of enzyme-catalyzed processes or miniaturized continuous flow systems allow fast high-throughput screenings. Continuous flow microreactor systems enabled integration of enzyme-catalysis with chemical steps (e.g., in dynamic kinetic resolutions) or with continuous extraction or performing multienzyme-catalyzed multistep biotransformations. Thus, the potential of continuous-flow microreactor systems with immobilized biocatalysts is demonstrated as process development tool for stereoselective biotransformations.

Original languageEnglish
Title of host publicationCascade Biocatalysis: Integrating Stereoselective and Environmentally Friendly Reactions
PublisherWiley Blackwell
Pages199-230
Number of pages32
ISBN (Print)9783527682492, 9783527335220
DOIs
Publication statusPublished - Sep 9 2014

Fingerprint

Hydrolases
Biotransformation
Enzymes
Systems Integration
Packed beds
Catalysis
Screening
Productivity
Throughput
Kinetics

Keywords

  • Continuous-flow reaction
  • Enzyme immobilization
  • Hydrolase
  • Microreactor
  • Strereoselective biotransformation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Boros, Z., Hornyánszky, G., Nagy, J., & Poppe, L. (2014). Stereoselective Hydrolase-Catalyzed Processes in Continuous-Flow Mode. In Cascade Biocatalysis: Integrating Stereoselective and Environmentally Friendly Reactions (pp. 199-230). Wiley Blackwell. https://doi.org/10.1002/9783527682492.ch9

Stereoselective Hydrolase-Catalyzed Processes in Continuous-Flow Mode. / Boros, Zoltán; Hornyánszky, Gábor; Nagy, József; Poppe, L.

Cascade Biocatalysis: Integrating Stereoselective and Environmentally Friendly Reactions. Wiley Blackwell, 2014. p. 199-230.

Research output: Chapter in Book/Report/Conference proceedingChapter

Boros, Z, Hornyánszky, G, Nagy, J & Poppe, L 2014, Stereoselective Hydrolase-Catalyzed Processes in Continuous-Flow Mode. in Cascade Biocatalysis: Integrating Stereoselective and Environmentally Friendly Reactions. Wiley Blackwell, pp. 199-230. https://doi.org/10.1002/9783527682492.ch9
Boros Z, Hornyánszky G, Nagy J, Poppe L. Stereoselective Hydrolase-Catalyzed Processes in Continuous-Flow Mode. In Cascade Biocatalysis: Integrating Stereoselective and Environmentally Friendly Reactions. Wiley Blackwell. 2014. p. 199-230 https://doi.org/10.1002/9783527682492.ch9
Boros, Zoltán ; Hornyánszky, Gábor ; Nagy, József ; Poppe, L. / Stereoselective Hydrolase-Catalyzed Processes in Continuous-Flow Mode. Cascade Biocatalysis: Integrating Stereoselective and Environmentally Friendly Reactions. Wiley Blackwell, 2014. pp. 199-230
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