Stereoselective distribution of acenocoumarol enantiomers in human plasma: Chiral chromatographic analysis of the ultrafiltrates

I. Fitos, J. Visy, M. Simonyi, J. Hermansson

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15 Citations (Scopus)

Abstract

Stereoselectivities for the binding of rac-acenocoumarol to human serum albumin (HSA), α1-acid glycoprotein (AGP), and human plasma were determined by chiral HPLC analysis of the ultrafiltrates on a Chiral-AGP column. The results confirmed the previously detected inverse stereoselectivities; for HSA the ratio of the enantiomeric constants was K(R)/K(S) ~ 2, while for AGP it was K(R)/K(S) ~ 0.3. In plasma the contribution of HSA dominates, although in pathological states, elevated AGP levels may compensate for stereo-selective distribution.

Original languageEnglish
Pages (from-to)346-349
Number of pages4
JournalChirality
Volume5
Issue number5
Publication statusPublished - 1993

Fingerprint

Acenocoumarol
Chromatographic analysis
Plasma (human)
Glycoproteins
Enantiomers
Chromatography
Serum Albumin
Stereoselectivity
Acids
High Pressure Liquid Chromatography
Plasmas

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

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abstract = "Stereoselectivities for the binding of rac-acenocoumarol to human serum albumin (HSA), α1-acid glycoprotein (AGP), and human plasma were determined by chiral HPLC analysis of the ultrafiltrates on a Chiral-AGP column. The results confirmed the previously detected inverse stereoselectivities; for HSA the ratio of the enantiomeric constants was K(R)/K(S) ~ 2, while for AGP it was K(R)/K(S) ~ 0.3. In plasma the contribution of HSA dominates, although in pathological states, elevated AGP levels may compensate for stereo-selective distribution.",
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T1 - Stereoselective distribution of acenocoumarol enantiomers in human plasma

T2 - Chiral chromatographic analysis of the ultrafiltrates

AU - Fitos, I.

AU - Visy, J.

AU - Simonyi, M.

AU - Hermansson, J.

PY - 1993

Y1 - 1993

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AB - Stereoselectivities for the binding of rac-acenocoumarol to human serum albumin (HSA), α1-acid glycoprotein (AGP), and human plasma were determined by chiral HPLC analysis of the ultrafiltrates on a Chiral-AGP column. The results confirmed the previously detected inverse stereoselectivities; for HSA the ratio of the enantiomeric constants was K(R)/K(S) ~ 2, while for AGP it was K(R)/K(S) ~ 0.3. In plasma the contribution of HSA dominates, although in pathological states, elevated AGP levels may compensate for stereo-selective distribution.

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