Stereoselective binding of benzodiazepines and related compounds on calmodulin‐sepharose

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Abstract

A method has been presented to evaluate the Ca2+‐dependent binding affinity of ligands to calmodulin (CaM) from their chromatographic retentions obtained on a CaM‐Sepharose column. Enantiomers of benzodiazepines and related compounds could be separated. Among chiral calcium antagonists, verapamil showed stereoselectivity of binding. © 1995 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalChirality
Volume7
Issue number2
DOIs
Publication statusPublished - 1995

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Keywords

  • affinity chromatography
  • benzodiazepines
  • calcium antagonists
  • chiral interaction
  • phenothiazines

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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