Stereoselective allosteric binding interaction on human serum albumin between ibuprofen and lorazepam acetate

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Abstract

The effect of ibuprofen enantiomers on the stereoselective binding of 3- acyloxy-1,4-benzodiazepines to human serum albumin (HSA) was studied using both native and Sepharose-immobilized protein. (S)-Lorazepam acetate exhibited considerably enhanced binding, especially in the presence of (+)- (S)-ibuprofen. The phenomenon is an indication of cooperative allosteric interaction between different binding sites during multiple cobinding of two ligands.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalChirality
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 3 1999

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Keywords

  • Benzodiazepines
  • Chiral chromatographic separation
  • Plasma protein

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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