Stereocontrolled Synthesis of Functionalized Azaheterocycles from Carbocycles through Oxidative Ring Opening/Reductive Ring Closing Protocols

L. Kiss, Lamiaa Ouchakour, Renáta A. Ábrahámi, Melinda Nonn

Research output: Contribution to journalReview article

Abstract

Fluorine-containing organic scaffolds are of significant interest in medicinal chemistry. The incorporation of fluorine into biomolecules can lead to remarkable changes in their physical, chemical, and biological properties. There are already many drugs on the market, which contain at least one fluorine atom. Saturated functionalized azaheterocycles as bioactive substances have gained increasing attention in pharmaceutical chemistry. Due to the high biorelevance of organofluorine molecules and the importance of N-heterocyclic compounds, selective stereocontrolled procedures to the access of new fluorine-containing saturated N-heterocycles are considered to be a hot research topic. This account summarizes the synthesis of functionalized and fluorine-containing saturated azaheterocycles starting from functionalized cycloalkenes and based on oxidative ring cleavage of diol intermediates followed by ring expansion with reductive amination.

Original languageEnglish
JournalChemical Record
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Fluorine
Pharmaceutical Chemistry
Cycloparaffins
Heterocyclic Compounds
Amination
Biomolecules
Scaffolds
Atoms
Molecules
Research
Pharmaceutical Preparations

Keywords

  • azaheterocycles
  • functionalization
  • oxidative ring opening
  • reductive amination
  • ring closing

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Chemical Engineering(all)
  • Materials Chemistry

Cite this

Stereocontrolled Synthesis of Functionalized Azaheterocycles from Carbocycles through Oxidative Ring Opening/Reductive Ring Closing Protocols. / Kiss, L.; Ouchakour, Lamiaa; Ábrahámi, Renáta A.; Nonn, Melinda.

In: Chemical Record, 01.01.2019.

Research output: Contribution to journalReview article

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