Enantioselective heterogeneous catalytic hydrogenation of pyruvic acid ethyl ester and benzylidene-acetone with Pd/C catalyst in the presence of (S)-proline was investigated, where the reductive alkylation of proline was observed. The structure of the main products was elucidated by different NMR methods and the configuration and predominant conformation of (-)-(S)-1-(1-Ethoxycarbonyl-ethyl)-pyrrolidine-(S)-2-carboxylic acid (1) was established.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry