Reductions of cis- and trans-decahydropyrido[2,1-b]quinazolin-11-ones (4), (3) and their quaternary salts (10), (9), prepared by means of dimethyl sulphate, have been investigated. Stereospecific or stereoselective formation of the unsubstituted tricycles was found, whereas the 5-methylperhydropyrido-[2,1- b]quinazolines were formed stereospecifically only in the case of the trans-derivatives. The relative configurations of the 5-methyl compounds were established by means of configurative correlation, and the steric structures of the r-4a,c-5a,t-11a- and r-4a,c-6a,c-11a-dodecahydropyrido[2,1-b]quinazolin-11- ones (5a) and (7a), respectively, were determined by X-ray diffraction analysis.
|Number of pages||6|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|Publication status||Published - Dec 1 1982|
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