Stereochemical studies, 105. saturated heterocycles, 109. Synthesis and steric structures of perhyoro-4, 1-benzoxazepin-2-ones

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

cis- and trans-2-Hydroxymethylcyclohexanol were cyclized with ethyl chloroacetate or ethyl 2-chloropropionate in the presence of sodium hydride to synthesize stereoisomeric perhydro-4,l-benzoxazepin-2-ones (4-9). The relative configurations and predominant conformation of the compounds prepared were confirmed by 4H and 13 NMR spectroscopy.

Original languageEnglish
Pages (from-to)4359-4366
Number of pages8
JournalTetrahedron
Volume43
Issue number19
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Stereochemical studies, 105. saturated heterocycles, 109. Synthesis and steric structures of perhyoro-4, 1-benzoxazepin-2-ones'. Together they form a unique fingerprint.

  • Cite this