The stem cells constitute a cell population which is able for self renewal and differentiation. Recent studies revealed a role for stem cells in the development and progression of malignant tumors. Tumor stem cells have been described first in leukemias. These cells have a unique phenotype, are clonogenic and responsible for the maintenance of the tumor growth. Further on similar cell populations were observed in several solid tumors as well. These cells show different sensitivity for therapeutical approaches than their daughter cells, which form the large mass of the tumor. Therefore tumors could be treated more efficiently if the stem cell population could be targetted. Based on the similarities between normal and tumor stem cells, one can suspect the normal stem cells as targets of the carcinogenic insults. Stem cell origin of several tumors has been proven. Mesenchymal stem cells of the bone marrow can contribute to the formation of tumor stroma and thus participate in tumor progression.
|Translated title of the contribution||Stem cells and tumor biology|
|Number of pages||6|
|Publication status||Published - Dec 1 2006|
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