Statistical model of the hippocampal CA3 region: I. The single-cell module: Bursting model of the pyramidal cell

T. Gröbler, G. Barna, P. Érdi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A model with intermediate complexity is introduced to reproduce the basic firing modes of the CA3 pyramidal cell. Our model consists of a single compartment, has two variables (membrane potential and internal calcium concentration), and involves two separate stages for interspike mechanisms and firing. Interspike dynamics is governed by voltage- and calcium-dependent ionic channels but no channel kinetics are provided. This model is suitable to be included in our statistical population model (Part II, following paper). Bifurcation analysis reveals that interspike dynamics rather than sodium firing has the dominant role in the control of bursting/nonbursting behavior.

Original languageEnglish
Pages (from-to)301-308
Number of pages8
JournalBiological Cybernetics
Volume79
Issue number4
DOIs
Publication statusPublished - Jan 1 1998

ASJC Scopus subject areas

  • Biotechnology
  • Computer Science(all)

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