Statistical determination of the proper sample size in multicomponent separations

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14 Citations (Scopus)


The Fourier analysis of multicomponent chromatograms is applied to chromatograms of diesel fuels. The concentration of the injected sample was varied over several orders of magnitude. The number of components, the average peak width, as well as the retention pattern were determined for all sample concentrations. The lower edge of the practical sample size is limited by the baseline noise, whereas the upper limit is set by column overload. By means of statistical analysis, those two boundaries were isolated and a method is proposed to determine the useful sample size for the analysis of any multicomponent mixture. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)129-139
Number of pages11
JournalJournal of Chromatography A
Issue number1-2
Publication statusPublished - Apr 16 1999


  • Diesel fuel
  • Fourier analysis
  • Sample size

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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