Stationary phase optimized selectivity liquid chromatography: Basic possibilities of serially connected columns using the "PRISMA" principle

S. Nyiredy, Zoltán Szucs, L. Szepesy

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

A new procedure (stationary phase optimized selectivity liquid chromatography: SOS-LC) is described for the optimization of the HPLC stationary phase, using serially connected columns and the principle of the "PRISMA" model. The retention factors (k) of the analytes were determined on three different stationary phases. By use of these data the k values were predicted applying theoretically combined stationary phases. These predictions resulted in numerous intermediate theoretical separations from among which only the optimal one was assembled and tested. The overall selectivity of this separation was better than that of any individual base stationary phase. SOS-LC is independent of the mechanism and the scale of separation.

Original languageEnglish
Pages (from-to)122-130
Number of pages9
JournalJournal of Chromatography A
Volume1157
Issue number1-2
DOIs
Publication statusPublished - Jul 20 2007

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Liquid chromatography
Liquid Chromatography
High Pressure Liquid Chromatography

Keywords

  • "PRISMA" principle
  • Liquid chromatography
  • Selectivity optimization
  • Serially connected columns
  • Stationary phase

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

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AB - A new procedure (stationary phase optimized selectivity liquid chromatography: SOS-LC) is described for the optimization of the HPLC stationary phase, using serially connected columns and the principle of the "PRISMA" model. The retention factors (k) of the analytes were determined on three different stationary phases. By use of these data the k values were predicted applying theoretically combined stationary phases. These predictions resulted in numerous intermediate theoretical separations from among which only the optimal one was assembled and tested. The overall selectivity of this separation was better than that of any individual base stationary phase. SOS-LC is independent of the mechanism and the scale of separation.

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