State-of-the-art MS technology applications in lung disease

Akos Végvri, B. Döme

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Two frontline MS technologies, which have recently gained much attention, are discussed within the scope of this review. Besides a brief summary on the contemporary state of lung cancer and chronic obstructive pulmonary disease, the principles of multiple reaction monitoring and matrix assisted laser desorption ionization (MALDI) MS imaging are presented. A comprehensive overview of quantitative mass spectrometry applications is provided, covering multiple reaction monitoring assay developments for analysis of proteins (biomarkers) and low-molecular-weight compounds (drugs) with a special focus on the disease areas of lung cancer and chronic obstructive pulmonary disease. The MALDI-MS imaging applications are discussed similarly, providing references to studies conducted on lung tissues in order to localize drug compounds and protein biomarkers.

Original languageEnglish
Pages (from-to)2665-2677
Number of pages13
JournalBioanalysis
Volume3
Issue number23
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Pulmonary diseases
Biomarkers
Chronic Obstructive Pulmonary Disease
Lung Diseases
Ionization
Desorption
Lung Neoplasms
Lasers
Technology
Imaging techniques
Monitoring
Pharmaceutical Preparations
Mass spectrometry
Assays
Mass Spectrometry
Proteins
Molecular Weight
Molecular weight
Tissue
Lung

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medical Laboratory Technology
  • Analytical Chemistry

Cite this

State-of-the-art MS technology applications in lung disease. / Végvri, Akos; Döme, B.

In: Bioanalysis, Vol. 3, No. 23, 12.2011, p. 2665-2677.

Research output: Contribution to journalArticle

Végvri, Akos ; Döme, B. / State-of-the-art MS technology applications in lung disease. In: Bioanalysis. 2011 ; Vol. 3, No. 23. pp. 2665-2677.
@article{ac03e7a155ce4317bd32f8edba778016,
title = "State-of-the-art MS technology applications in lung disease",
abstract = "Two frontline MS technologies, which have recently gained much attention, are discussed within the scope of this review. Besides a brief summary on the contemporary state of lung cancer and chronic obstructive pulmonary disease, the principles of multiple reaction monitoring and matrix assisted laser desorption ionization (MALDI) MS imaging are presented. A comprehensive overview of quantitative mass spectrometry applications is provided, covering multiple reaction monitoring assay developments for analysis of proteins (biomarkers) and low-molecular-weight compounds (drugs) with a special focus on the disease areas of lung cancer and chronic obstructive pulmonary disease. The MALDI-MS imaging applications are discussed similarly, providing references to studies conducted on lung tissues in order to localize drug compounds and protein biomarkers.",
author = "Akos V{\'e}gvri and B. D{\"o}me",
year = "2011",
month = "12",
doi = "10.4155/bio.11.271",
language = "English",
volume = "3",
pages = "2665--2677",
journal = "Bioanalysis",
issn = "1757-6180",
publisher = "Future Science",
number = "23",

}

TY - JOUR

T1 - State-of-the-art MS technology applications in lung disease

AU - Végvri, Akos

AU - Döme, B.

PY - 2011/12

Y1 - 2011/12

N2 - Two frontline MS technologies, which have recently gained much attention, are discussed within the scope of this review. Besides a brief summary on the contemporary state of lung cancer and chronic obstructive pulmonary disease, the principles of multiple reaction monitoring and matrix assisted laser desorption ionization (MALDI) MS imaging are presented. A comprehensive overview of quantitative mass spectrometry applications is provided, covering multiple reaction monitoring assay developments for analysis of proteins (biomarkers) and low-molecular-weight compounds (drugs) with a special focus on the disease areas of lung cancer and chronic obstructive pulmonary disease. The MALDI-MS imaging applications are discussed similarly, providing references to studies conducted on lung tissues in order to localize drug compounds and protein biomarkers.

AB - Two frontline MS technologies, which have recently gained much attention, are discussed within the scope of this review. Besides a brief summary on the contemporary state of lung cancer and chronic obstructive pulmonary disease, the principles of multiple reaction monitoring and matrix assisted laser desorption ionization (MALDI) MS imaging are presented. A comprehensive overview of quantitative mass spectrometry applications is provided, covering multiple reaction monitoring assay developments for analysis of proteins (biomarkers) and low-molecular-weight compounds (drugs) with a special focus on the disease areas of lung cancer and chronic obstructive pulmonary disease. The MALDI-MS imaging applications are discussed similarly, providing references to studies conducted on lung tissues in order to localize drug compounds and protein biomarkers.

UR - http://www.scopus.com/inward/record.url?scp=82955168436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82955168436&partnerID=8YFLogxK

U2 - 10.4155/bio.11.271

DO - 10.4155/bio.11.271

M3 - Article

VL - 3

SP - 2665

EP - 2677

JO - Bioanalysis

JF - Bioanalysis

SN - 1757-6180

IS - 23

ER -