State of the art in vivo imaging techniques for laboratory animals

David Tibor Lauber, András Fülöp, T. Kovács, Krisztián Szigeti, Domokos Máthé, Attila Szijártó

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

In recent decades, imaging devices have become indispensable tools in the basic sciences, in preclinical research and in modern drug development. The rapidly evolving high-resolution in vivo imaging technologies provide a unique opportunity for studying biological processes of living organisms in real time on a molecular level. State of the art small-animal imaging modalities provide non-invasive images rich in quantitative anatomical and functional information, which renders longitudinal studies possible allowing precise monitoring of disease progression and response to therapy in models of different diseases. The number of animals in a scientific investigation can be substantially reduced using imaging techniques, which is in full compliance with the ethical endeavours for the 3R (reduction, refinement, replacement) policies formulated by Russell and Burch; furthermore, biological variability can be alleviated, as each animal serves as its own control. The most suitable and commonly used imaging modalities for in vivo small-animal imaging are optical imaging (OI), ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and finally the methods of nuclear medicine: positron emission tomography (PET) and single photon emission computed tomography (SPECT).

Original languageEnglish
Pages (from-to)465-478
Number of pages14
JournalLaboratory Animals
Volume51
Issue number5
DOIs
Publication statusPublished - Oct 1 2017

Fingerprint

Laboratory Animals
laboratory animals
image analysis
Biological Phenomena
computed tomography
Optical Imaging
Nuclear Medicine
Single-Photon Emission-Computed Tomography
methodology
animals
Positron-Emission Tomography
Longitudinal Studies
Disease Progression
Ultrasonography
positron-emission tomography
Tomography
Magnetic Resonance Imaging
Technology
disease models
Equipment and Supplies

Keywords

  • CT
  • imaging modalities
  • molecular imaging
  • MRI
  • optical imaging

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Lauber, D. T., Fülöp, A., Kovács, T., Szigeti, K., Máthé, D., & Szijártó, A. (2017). State of the art in vivo imaging techniques for laboratory animals. Laboratory Animals, 51(5), 465-478. https://doi.org/10.1177/0023677217695852

State of the art in vivo imaging techniques for laboratory animals. / Lauber, David Tibor; Fülöp, András; Kovács, T.; Szigeti, Krisztián; Máthé, Domokos; Szijártó, Attila.

In: Laboratory Animals, Vol. 51, No. 5, 01.10.2017, p. 465-478.

Research output: Contribution to journalReview article

Lauber, DT, Fülöp, A, Kovács, T, Szigeti, K, Máthé, D & Szijártó, A 2017, 'State of the art in vivo imaging techniques for laboratory animals', Laboratory Animals, vol. 51, no. 5, pp. 465-478. https://doi.org/10.1177/0023677217695852
Lauber, David Tibor ; Fülöp, András ; Kovács, T. ; Szigeti, Krisztián ; Máthé, Domokos ; Szijártó, Attila. / State of the art in vivo imaging techniques for laboratory animals. In: Laboratory Animals. 2017 ; Vol. 51, No. 5. pp. 465-478.
@article{ed29814c1109466887cf359f1c99a4b7,
title = "State of the art in vivo imaging techniques for laboratory animals",
abstract = "In recent decades, imaging devices have become indispensable tools in the basic sciences, in preclinical research and in modern drug development. The rapidly evolving high-resolution in vivo imaging technologies provide a unique opportunity for studying biological processes of living organisms in real time on a molecular level. State of the art small-animal imaging modalities provide non-invasive images rich in quantitative anatomical and functional information, which renders longitudinal studies possible allowing precise monitoring of disease progression and response to therapy in models of different diseases. The number of animals in a scientific investigation can be substantially reduced using imaging techniques, which is in full compliance with the ethical endeavours for the 3R (reduction, refinement, replacement) policies formulated by Russell and Burch; furthermore, biological variability can be alleviated, as each animal serves as its own control. The most suitable and commonly used imaging modalities for in vivo small-animal imaging are optical imaging (OI), ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and finally the methods of nuclear medicine: positron emission tomography (PET) and single photon emission computed tomography (SPECT).",
keywords = "CT, imaging modalities, molecular imaging, MRI, optical imaging",
author = "Lauber, {David Tibor} and Andr{\'a}s F{\"u}l{\"o}p and T. Kov{\'a}cs and Kriszti{\'a}n Szigeti and Domokos M{\'a}th{\'e} and Attila Szij{\'a}rt{\'o}",
year = "2017",
month = "10",
day = "1",
doi = "10.1177/0023677217695852",
language = "English",
volume = "51",
pages = "465--478",
journal = "Laboratory Animals",
issn = "0023-6772",
publisher = "SAGE Publications Ltd",
number = "5",

}

TY - JOUR

T1 - State of the art in vivo imaging techniques for laboratory animals

AU - Lauber, David Tibor

AU - Fülöp, András

AU - Kovács, T.

AU - Szigeti, Krisztián

AU - Máthé, Domokos

AU - Szijártó, Attila

PY - 2017/10/1

Y1 - 2017/10/1

N2 - In recent decades, imaging devices have become indispensable tools in the basic sciences, in preclinical research and in modern drug development. The rapidly evolving high-resolution in vivo imaging technologies provide a unique opportunity for studying biological processes of living organisms in real time on a molecular level. State of the art small-animal imaging modalities provide non-invasive images rich in quantitative anatomical and functional information, which renders longitudinal studies possible allowing precise monitoring of disease progression and response to therapy in models of different diseases. The number of animals in a scientific investigation can be substantially reduced using imaging techniques, which is in full compliance with the ethical endeavours for the 3R (reduction, refinement, replacement) policies formulated by Russell and Burch; furthermore, biological variability can be alleviated, as each animal serves as its own control. The most suitable and commonly used imaging modalities for in vivo small-animal imaging are optical imaging (OI), ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and finally the methods of nuclear medicine: positron emission tomography (PET) and single photon emission computed tomography (SPECT).

AB - In recent decades, imaging devices have become indispensable tools in the basic sciences, in preclinical research and in modern drug development. The rapidly evolving high-resolution in vivo imaging technologies provide a unique opportunity for studying biological processes of living organisms in real time on a molecular level. State of the art small-animal imaging modalities provide non-invasive images rich in quantitative anatomical and functional information, which renders longitudinal studies possible allowing precise monitoring of disease progression and response to therapy in models of different diseases. The number of animals in a scientific investigation can be substantially reduced using imaging techniques, which is in full compliance with the ethical endeavours for the 3R (reduction, refinement, replacement) policies formulated by Russell and Burch; furthermore, biological variability can be alleviated, as each animal serves as its own control. The most suitable and commonly used imaging modalities for in vivo small-animal imaging are optical imaging (OI), ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and finally the methods of nuclear medicine: positron emission tomography (PET) and single photon emission computed tomography (SPECT).

KW - CT

KW - imaging modalities

KW - molecular imaging

KW - MRI

KW - optical imaging

UR - http://www.scopus.com/inward/record.url?scp=85030120327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030120327&partnerID=8YFLogxK

U2 - 10.1177/0023677217695852

DO - 10.1177/0023677217695852

M3 - Review article

C2 - 28948893

AN - SCOPUS:85030120327

VL - 51

SP - 465

EP - 478

JO - Laboratory Animals

JF - Laboratory Animals

SN - 0023-6772

IS - 5

ER -