Abstract
In recent decades, imaging devices have become indispensable tools in the basic sciences, in preclinical research and in modern drug development. The rapidly evolving high-resolution in vivo imaging technologies provide a unique opportunity for studying biological processes of living organisms in real time on a molecular level. State of the art small-animal imaging modalities provide non-invasive images rich in quantitative anatomical and functional information, which renders longitudinal studies possible allowing precise monitoring of disease progression and response to therapy in models of different diseases. The number of animals in a scientific investigation can be substantially reduced using imaging techniques, which is in full compliance with the ethical endeavours for the 3R (reduction, refinement, replacement) policies formulated by Russell and Burch; furthermore, biological variability can be alleviated, as each animal serves as its own control. The most suitable and commonly used imaging modalities for in vivo small-animal imaging are optical imaging (OI), ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and finally the methods of nuclear medicine: positron emission tomography (PET) and single photon emission computed tomography (SPECT).
| Original language | English |
|---|---|
| Pages (from-to) | 465-478 |
| Number of pages | 14 |
| Journal | Laboratory Animals |
| Volume | 51 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 1 2017 |
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Keywords
- CT
- imaging modalities
- molecular imaging
- MRI
- optical imaging
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
State of the art in vivo imaging techniques for laboratory animals. / Lauber, David Tibor; Fülöp, András; Kovács, T.; Szigeti, Krisztián; Máthé, Domokos; Szijártó, Attila.
In: Laboratory Animals, Vol. 51, No. 5, 01.10.2017, p. 465-478.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - State of the art in vivo imaging techniques for laboratory animals
AU - Lauber, David Tibor
AU - Fülöp, András
AU - Kovács, T.
AU - Szigeti, Krisztián
AU - Máthé, Domokos
AU - Szijártó, Attila
PY - 2017/10/1
Y1 - 2017/10/1
N2 - In recent decades, imaging devices have become indispensable tools in the basic sciences, in preclinical research and in modern drug development. The rapidly evolving high-resolution in vivo imaging technologies provide a unique opportunity for studying biological processes of living organisms in real time on a molecular level. State of the art small-animal imaging modalities provide non-invasive images rich in quantitative anatomical and functional information, which renders longitudinal studies possible allowing precise monitoring of disease progression and response to therapy in models of different diseases. The number of animals in a scientific investigation can be substantially reduced using imaging techniques, which is in full compliance with the ethical endeavours for the 3R (reduction, refinement, replacement) policies formulated by Russell and Burch; furthermore, biological variability can be alleviated, as each animal serves as its own control. The most suitable and commonly used imaging modalities for in vivo small-animal imaging are optical imaging (OI), ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and finally the methods of nuclear medicine: positron emission tomography (PET) and single photon emission computed tomography (SPECT).
AB - In recent decades, imaging devices have become indispensable tools in the basic sciences, in preclinical research and in modern drug development. The rapidly evolving high-resolution in vivo imaging technologies provide a unique opportunity for studying biological processes of living organisms in real time on a molecular level. State of the art small-animal imaging modalities provide non-invasive images rich in quantitative anatomical and functional information, which renders longitudinal studies possible allowing precise monitoring of disease progression and response to therapy in models of different diseases. The number of animals in a scientific investigation can be substantially reduced using imaging techniques, which is in full compliance with the ethical endeavours for the 3R (reduction, refinement, replacement) policies formulated by Russell and Burch; furthermore, biological variability can be alleviated, as each animal serves as its own control. The most suitable and commonly used imaging modalities for in vivo small-animal imaging are optical imaging (OI), ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI), and finally the methods of nuclear medicine: positron emission tomography (PET) and single photon emission computed tomography (SPECT).
KW - CT
KW - imaging modalities
KW - molecular imaging
KW - MRI
KW - optical imaging
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UR - http://www.scopus.com/inward/citedby.url?scp=85030120327&partnerID=8YFLogxK
U2 - 10.1177/0023677217695852
DO - 10.1177/0023677217695852
M3 - Review article
C2 - 28948893
AN - SCOPUS:85030120327
VL - 51
SP - 465
EP - 478
JO - Laboratory Animals
JF - Laboratory Animals
SN - 0023-6772
IS - 5
ER -