Standardizing the MR image intensity scales: Making MR intensities have tissue specific meaning

Laszlo G. Nyul, Jayaram K. Udupa

Research output: Contribution to journalConference article

11 Citations (Scopus)


One of the major drawbacks of Magnetic Resonance Imaging (MRI) has been the lack of a standard and quantifiable interpretation of image intensities. Unlike in other modalities such as x-ray computerized tomography, MR images taken for the same patient on the same scanner at different times may appear different from each other due to a variety of scanner-dependent variations, and therefore, the absolute intensity values do not have a fixed meaning. We have devised a two-step method wherein all images (independent of patients and the specific brand of the MR scanner used) can be transformed in such a way that for the same protocol and body region, in the transformed images similar intensities will have similar tissue meaning. Standardized images can be displayed with fixed windows without the need of per case adjustment. More importantly, extraction of quantitative information about healthy organs or about abnormalities can be considerably simplified. This paper introduces and compares new variants of this standardizing method that can help to overcome some of the problems with the original method.

Original languageEnglish
Pages (from-to)496-504
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - Jan 1 2000
EventMedical Imaging 2000: Image Display and Visualization - San Diego, CA, USA
Duration: Feb 13 2000Feb 15 2000


ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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