Stage related detection rate of human papillomavirus DNA in invasive cervical cancer

R. Poka, J. Czegledy, Z. Hernádi, L. Gergely, L. Lampe

Research output: Contribution to journalArticle

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Abstract

Histologically proved cervical carcinoma tissue samples from 50 patients were analysed for the presence of human papillomavirus types 6, II, 16 and 18 deoxyribonucleic acid sequences. P'2 labelled papillomavirus test-DNAs were analysed by Southern blot hybridisation. Viral types 16 and 18 have high prevalences in cervical carcinoma tissues and they may play a role in cervical carcinogenesis. Increasing detection rates of oncogenic viral types were found in more advanced stages. Results suggest that human papillomaviruses are involved in the progression of the disease as well as in its initiation.

Original languageEnglish
Pages (from-to)448-450
Number of pages3
JournalJournal of Obstetrics and Gynaecology
Volume11
Issue number6
DOIs
Publication statusPublished - 1991

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Uterine Cervical Neoplasms
Human papillomavirus 6
Carcinoma
Human papillomavirus 18
DNA
Southern Blotting
Disease Progression
Carcinogenesis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Stage related detection rate of human papillomavirus DNA in invasive cervical cancer. / Poka, R.; Czegledy, J.; Hernádi, Z.; Gergely, L.; Lampe, L.

In: Journal of Obstetrics and Gynaecology, Vol. 11, No. 6, 1991, p. 448-450.

Research output: Contribution to journalArticle

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