Stability of multiple emulsions. I. Determination of factors influencing multiple drop breakdown

I. Csóka, I. Erõs

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Abstract

The paper describes a method to study the stability of w/o/w (water/oil/water) multiple drops by means of an ion-selective membrane-electrode, using a marker compound, ephedrine HCl. The effect of the 1st emulsifier concentration and the influence of the w/o emulsion ratio on the stability were investigated. An exponential equation and a power-function relationship were found to characterize the multiple drop breakdown during storage. The less the w/o emulsion ratio and the higher the 1st emulsifier concentration, the slower the multiple drop number decrease rate.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalInternational Journal of Pharmaceutics
Volume156
Issue number1
DOIs
Publication statusPublished - Oct 10 1997

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Keywords

  • Ephedrine HCl
  • Ion-selective membrane electrode
  • Multiple phase emulsion
  • Ratio of w/o emulsion
  • Stability of droplets
  • Surfactant

ASJC Scopus subject areas

  • Pharmaceutical Science

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