The authors examined the stability of the non-steroidal anti-inflammatory drugs diclofenac sodium and piroxicam in new, semi-solid gel systems suitable for topical 'soft-patch' formulations. The decomposition of active substances in the stearate and lipophilic gels during storage at 4, 25 and 40°C was studied using high performance liquid chromatography (HPLC). The quantities of non-decomposed active substances were selectively determined. The decomposition rates of active substances and the expiry dates for gel formulations were calculated. It was concluded that both the active ingredients tested were chemically more stable in the case of the stearate gel.
|Number of pages||4|
|Journal||S.T.P. Pharma Sciences|
|Publication status||Published - Jan 1 2000|
- Diclofenac sodium
- High performance liquid chromtography
ASJC Scopus subject areas
- Pharmaceutical Science