Stability of diclofenac sodium and piroxicam in new transdermal 'soft-patch' type gel systems

G. Csoka, S. Marton, R. Zelko, I. Racz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The authors examined the stability of the non-steroidal anti-inflammatory drugs diclofenac sodium and piroxicam in new, semi-solid gel systems suitable for topical 'soft-patch' formulations. The decomposition of active substances in the stearate and lipophilic gels during storage at 4, 25 and 40°C was studied using high performance liquid chromatography (HPLC). The quantities of non-decomposed active substances were selectively determined. The decomposition rates of active substances and the expiry dates for gel formulations were calculated. It was concluded that both the active ingredients tested were chemically more stable in the case of the stearate gel.

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalS.T.P. Pharma Sciences
Volume10
Issue number5
Publication statusPublished - Jan 1 2000

Keywords

  • Diclofenac sodium
  • High performance liquid chromtography
  • Piroxicam
  • Soft-patch
  • Stability

ASJC Scopus subject areas

  • Pharmaceutical Science

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