Stability of cisplatin containing infusions

András Mittner, Z. Vincze, K. Jemnitz

Research output: Contribution to journalArticle

3 Citations (Scopus)


The stability of cisplatin containing normal saline admixture solution for infusion at various temperatures has been studied. The difference in stability between storage at room temperature and at 2-8 °C was observed based on an HPLC assay. Stored in a refrigerator, the decomposition of the drug was less than 1% on the third day, and remained under 2.6% even on the seventh day. Under room temperature the decomposition exceeded 2% on the third and was over 15% on the seventh day. Cooling the admixture resulted in a 4-fold increase of T 1/4 of the decomposition (27.5 days and 134.4 days at 22-24 °C and 2-8 °C, respectively).

Original languageEnglish
Pages (from-to)490-492
Number of pages3
Issue number7
Publication statusPublished - Jan 1 1998

ASJC Scopus subject areas

  • Pharmaceutical Science

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    Mittner, A., Vincze, Z., & Jemnitz, K. (1998). Stability of cisplatin containing infusions. Pharmazie, 53(7), 490-492.