The stability of cisplatin containing normal saline admixture solution for infusion at various temperatures has been studied. The difference in stability between storage at room temperature and at 2-8 °C was observed based on an HPLC assay. Stored in a refrigerator, the decomposition of the drug was less than 1% on the third day, and remained under 2.6% even on the seventh day. Under room temperature the decomposition exceeded 2% on the third and was over 15% on the seventh day. Cooling the admixture resulted in a 4-fold increase of T 1/4 of the decomposition (27.5 days and 134.4 days at 22-24 °C and 2-8 °C, respectively).
|Number of pages||3|
|Publication status||Published - Jan 1 1998|
ASJC Scopus subject areas
- Pharmaceutical Science