Stability constants and 1H relaxation effects of ternary complexes formed between Gd-DTPA, Gd-DTPA-BMA, Gd-DOTA, and Gd-EDTA and citrate, phosphate, and carbonate ions

László Burai, Vesa Hietapelto, R. Király, Éva Tóth, E. Brücher

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54 Citations (Scopus)

Abstract

Formation of ternary complexes between Gd-DTPA, Gd-DTPA-BMA, and Gd- DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligible at around pH <8. The complex Gd-EDTA forms more stable ternary complexes with carbonate and phosphate and it also strongly coordinates the terdentate citrate ligand. The formation of ternary complexes Gd-EDTA(X) (X = CO32-, Cit3-) results in a significant decrease in the proton relaxation rates under physiological conditions.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalMagnetic Resonance in Medicine
Volume38
Issue number1
DOIs
Publication statusPublished - Jul 1997

Fingerprint

gadodiamide
Gadolinium DTPA
Carbonates
Citric Acid
Protons
Phosphates
Ions
Contrast Media
Ligands
gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate
gadolinium EDTA

Keywords

  • Contrast agents
  • Relaxivity
  • Stability constants
  • Ternary complexes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

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abstract = "Formation of ternary complexes between Gd-DTPA, Gd-DTPA-BMA, and Gd- DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligible at around pH <8. The complex Gd-EDTA forms more stable ternary complexes with carbonate and phosphate and it also strongly coordinates the terdentate citrate ligand. The formation of ternary complexes Gd-EDTA(X) (X = CO32-, Cit3-) results in a significant decrease in the proton relaxation rates under physiological conditions.",
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T1 - Stability constants and 1H relaxation effects of ternary complexes formed between Gd-DTPA, Gd-DTPA-BMA, Gd-DOTA, and Gd-EDTA and citrate, phosphate, and carbonate ions

AU - Burai, László

AU - Hietapelto, Vesa

AU - Király, R.

AU - Tóth, Éva

AU - Brücher, E.

PY - 1997/7

Y1 - 1997/7

N2 - Formation of ternary complexes between Gd-DTPA, Gd-DTPA-BMA, and Gd- DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligible at around pH <8. The complex Gd-EDTA forms more stable ternary complexes with carbonate and phosphate and it also strongly coordinates the terdentate citrate ligand. The formation of ternary complexes Gd-EDTA(X) (X = CO32-, Cit3-) results in a significant decrease in the proton relaxation rates under physiological conditions.

AB - Formation of ternary complexes between Gd-DTPA, Gd-DTPA-BMA, and Gd- DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligible at around pH <8. The complex Gd-EDTA forms more stable ternary complexes with carbonate and phosphate and it also strongly coordinates the terdentate citrate ligand. The formation of ternary complexes Gd-EDTA(X) (X = CO32-, Cit3-) results in a significant decrease in the proton relaxation rates under physiological conditions.

KW - Contrast agents

KW - Relaxivity

KW - Stability constants

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