Stability assessment of o/w parenteral nutrition emulsions in the presence of high glucose and calcium concentrations

I. G. Télessy, J. Balogh, J. Turmezei, J. Dredán, R. Zelkó

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The purpose of the present study was to examine how the colloid stability features of o/w parenteral nutrition emulsions made with SMOFlipid (lipid emulsion based on soybean oil, medium chain triglycerides, olive oil and fish oil) will change in the presence of high concentration of calcium and glucose if usual micronutrients are also present, according to the needs of the clinical nutrition patient. Particle size analysis, zeta potential, dynamic surface tension measurements and light microscopic screening were carried out to evaluate the possible changes in the kinetic stability of the emulsions. Our results indicate that the higher glucose concentration of 15 or 20% could not compensate the emulsion-destabilizing effect of higher (5mM) calcium concentration even in the presence of a modern fat emulsion. Therefore calcium demand of undernourished patient requiring 5mM or higher final Ca 2+ content in nutrient solution should be supplemented in another way.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume56
Issue number2
DOIs
Publication statusPublished - Sep 10 2011

Fingerprint

Parenteral Nutrition
Nutrition
Emulsions
Calcium
Glucose
Soybean Oil
Surface Tension
Fish Oils
Micronutrients
Colloids
Zeta potential
Particle Size
Particle size analysis
Surface tension
Screening
Triglycerides
Fats
Lipids
Light
Kinetics

Keywords

  • Calcium concentration
  • Glucose concentration
  • Kinetic stability
  • O/w Emulsions
  • SMOFlipid
  • Total nutrient admixtures (TNAs)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Spectroscopy
  • Clinical Biochemistry

Cite this

Stability assessment of o/w parenteral nutrition emulsions in the presence of high glucose and calcium concentrations. / Télessy, I. G.; Balogh, J.; Turmezei, J.; Dredán, J.; Zelkó, R.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 56, No. 2, 10.09.2011, p. 159-164.

Research output: Contribution to journalArticle

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