Stability and Toxicity of Contrast Agents

Erño Brücher, Gyula Tircsó, Zsolt Baranyai, Zoltán Kovács, A. Dean Sherry

Research output: Chapter in Book/Report/Conference proceedingChapter

41 Citations (Scopus)

Abstract

The chapter on stability and toxicity of contrast agents gives an update of thermodynamic and kinetic constants for new metal ion-ligand complexes that are explored as a potential MRI contrast agents. It also provides a brief overview of the computer programs used for the calculation of the equilibrium constants (protonation and stability constants). Next, the chapter talks about stability of metal-ligand complexes, including complexes of open chain ligands, complexes of tripodal and 6-amino-6-methylperhydro-1,4-diazepine tetraacetic acid (AAZTA) ligands, and complexes of macrocyclic ligands. It also includes ternary complexes formed between the Ln(L) complexes and various bio-ligands, Mn 2+-based contrast agents. Then, it explains formation kinetics and dissociation of M(L) complexes such as DOTA complexes and DOTA-tetraamides complexes. Finally, the chapter discusses biodistribution and in vivo toxicity of Gd3+-based MRI contrast agents.

Original languageEnglish
Title of host publicationThe Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging
Subtitle of host publicationSecond Edition
PublisherJohn Wiley and Sons
Pages157-208
Number of pages52
ISBN (Print)9781119991762
DOIs
Publication statusPublished - Feb 18 2013

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Keywords

  • Equilibrium constants
  • Gadolinium (3+)
  • Kinetic inertness
  • MRI contrast agents
  • Metal-ligand complexes
  • Thermodynamic stability
  • in vivo toxicity

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Brücher, E., Tircsó, G., Baranyai, Z., Kovács, Z., & Sherry, A. D. (2013). Stability and Toxicity of Contrast Agents. In The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging: Second Edition (pp. 157-208). John Wiley and Sons. https://doi.org/10.1002/9781118503652.ch4