Stabilisation of SWNTs by alkyl-sulfate chitosan derivatives of different molecular weight: Towards the preparation of hybrids with anticoagulant properties

Dimitrios G. Fatouros, Kieron Power, Omar Kadir, I. Dékány, Spyros N. Yannopoulos, Nikolaos Bouropoulos, Aristides Bakandritsos, Milan D. Antonijevic, George D. Zouganelis, Marta Roldo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We have previously demonstrated that chitosan derivative N-octyl-O-sulfate chitosan (NOSC), which presents important pharmacological properties, can suspend single walled carbon nanotubes (SWNTs) up to 20 times more effectively than other chitosan derivatives in an aqueous environment. In an attempt to further investigate the impact of different molecular weights of chitosan to the solubilization and anticoagulant properties of these hybrids an array of NOSC derivatives varying their molecular weight (low, medium and high respectively) was synthesised and characterised by means of FT-IR spectroscopy, NMR spectroscopy and thermal gravimetric analysis (TGA). Microwave and nitric acid purified SWNTs, characterised by FT-IR spectroscopy, transmission electron microscopy (TEM) and Raman spectroscopy, were colloidally stabilised by these polymers and their anticoagulant activity was assessed. The results revealed that the low molecular weight NOSC coated SWNTs exhibit the highest activity when 0.5 mg mL-1 NOSC solutions are used, activity which is similar to that of the free polymer. Preliminary studies by exposure of these hybrids to Brine Shrimp (Artemia) cysts revealed no effect on the viability of sub-adult Artemia. Our findings suggest the possibility of tailoring these nanomaterials to bear the required properties for application as biocompatible building blocks for nanodevices including biosensors and biomaterials.

Original languageEnglish
Pages (from-to)1218-1224
Number of pages7
JournalNanoscale
Volume3
Issue number3
DOIs
Publication statusPublished - Mar 2011

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Single-walled carbon nanotubes (SWCN)
Chitosan
Anticoagulants
Stabilization
Molecular weight
Derivatives
Infrared spectroscopy
Polymers
Nitric Acid
Gravimetric analysis
Biocompatible Materials
Nanostructured materials
Biosensors
Nuclear magnetic resonance spectroscopy
Raman spectroscopy
Microwaves
Transmission electron microscopy
Nitric acid
N-octyl-O-sulfate chitosan
chitosan sulfate

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Stabilisation of SWNTs by alkyl-sulfate chitosan derivatives of different molecular weight : Towards the preparation of hybrids with anticoagulant properties. / Fatouros, Dimitrios G.; Power, Kieron; Kadir, Omar; Dékány, I.; Yannopoulos, Spyros N.; Bouropoulos, Nikolaos; Bakandritsos, Aristides; Antonijevic, Milan D.; Zouganelis, George D.; Roldo, Marta.

In: Nanoscale, Vol. 3, No. 3, 03.2011, p. 1218-1224.

Research output: Contribution to journalArticle

Fatouros, DG, Power, K, Kadir, O, Dékány, I, Yannopoulos, SN, Bouropoulos, N, Bakandritsos, A, Antonijevic, MD, Zouganelis, GD & Roldo, M 2011, 'Stabilisation of SWNTs by alkyl-sulfate chitosan derivatives of different molecular weight: Towards the preparation of hybrids with anticoagulant properties', Nanoscale, vol. 3, no. 3, pp. 1218-1224. https://doi.org/10.1039/c0nr00952k
Fatouros, Dimitrios G. ; Power, Kieron ; Kadir, Omar ; Dékány, I. ; Yannopoulos, Spyros N. ; Bouropoulos, Nikolaos ; Bakandritsos, Aristides ; Antonijevic, Milan D. ; Zouganelis, George D. ; Roldo, Marta. / Stabilisation of SWNTs by alkyl-sulfate chitosan derivatives of different molecular weight : Towards the preparation of hybrids with anticoagulant properties. In: Nanoscale. 2011 ; Vol. 3, No. 3. pp. 1218-1224.
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