Stabilisation of SWNTs by alkyl-sulfate chitosan derivatives of different molecular weight: Towards the preparation of hybrids with anticoagulant properties

Dimitrios G. Fatouros, Kieron Power, Omar Kadir, Imre Dékány, Spyros N. Yannopoulos, Nikolaos Bouropoulos, Aristides Bakandritsos, Milan D. Antonijevic, George D. Zouganelis, Marta Roldo

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Abstract

We have previously demonstrated that chitosan derivative N-octyl-O-sulfate chitosan (NOSC), which presents important pharmacological properties, can suspend single walled carbon nanotubes (SWNTs) up to 20 times more effectively than other chitosan derivatives in an aqueous environment. In an attempt to further investigate the impact of different molecular weights of chitosan to the solubilization and anticoagulant properties of these hybrids an array of NOSC derivatives varying their molecular weight (low, medium and high respectively) was synthesised and characterised by means of FT-IR spectroscopy, NMR spectroscopy and thermal gravimetric analysis (TGA). Microwave and nitric acid purified SWNTs, characterised by FT-IR spectroscopy, transmission electron microscopy (TEM) and Raman spectroscopy, were colloidally stabilised by these polymers and their anticoagulant activity was assessed. The results revealed that the low molecular weight NOSC coated SWNTs exhibit the highest activity when 0.5 mg mL-1 NOSC solutions are used, activity which is similar to that of the free polymer. Preliminary studies by exposure of these hybrids to Brine Shrimp (Artemia) cysts revealed no effect on the viability of sub-adult Artemia. Our findings suggest the possibility of tailoring these nanomaterials to bear the required properties for application as biocompatible building blocks for nanodevices including biosensors and biomaterials.

Original languageEnglish
Pages (from-to)1218-1224
Number of pages7
JournalNanoscale
Volume3
Issue number3
DOIs
Publication statusPublished - Mar 1 2011

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ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Fatouros, D. G., Power, K., Kadir, O., Dékány, I., Yannopoulos, S. N., Bouropoulos, N., Bakandritsos, A., Antonijevic, M. D., Zouganelis, G. D., & Roldo, M. (2011). Stabilisation of SWNTs by alkyl-sulfate chitosan derivatives of different molecular weight: Towards the preparation of hybrids with anticoagulant properties. Nanoscale, 3(3), 1218-1224. https://doi.org/10.1039/c0nr00952k