Stabilisation of peptide foldamers in an aqueous medium by incorporation of azapeptide building blocks

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Stable foldamers in water: Helical peptidic foldamers including H12 and H10/12 helices were constructed and stabilised in water. The foldamers' extra rigidity stems from the strong hydrogen bonding network of the azapeptide groups (see graphic).

Original languageEnglish
Pages (from-to)10736-10741
Number of pages6
JournalChemistry - A European Journal
Volume15
Issue number41
DOIs
Publication statusPublished - Oct 19 2009

Fingerprint

Peptides
Stabilization
Water
Rigidity
Hydrogen bonds

Keywords

  • Amino acids
  • Chirality
  • Foldamers
  • Peptides
  • Peptidomimetics

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

@article{f9188109893046d7972ac973d8dcd465,
title = "Stabilisation of peptide foldamers in an aqueous medium by incorporation of azapeptide building blocks",
abstract = "Stable foldamers in water: Helical peptidic foldamers including H12 and H10/12 helices were constructed and stabilised in water. The foldamers' extra rigidity stems from the strong hydrogen bonding network of the azapeptide groups (see graphic).",
keywords = "Amino acids, Chirality, Foldamers, Peptides, Peptidomimetics",
author = "A. Het{\'e}nyi and G. T{\'o}th and C. Somlai and E. Vass and T. Martinek and F. F{\"u}l{\"o}p",
year = "2009",
month = "10",
day = "19",
doi = "10.1002/chem.200900724",
language = "English",
volume = "15",
pages = "10736--10741",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "41",

}

TY - JOUR

T1 - Stabilisation of peptide foldamers in an aqueous medium by incorporation of azapeptide building blocks

AU - Hetényi, A.

AU - Tóth, G.

AU - Somlai, C.

AU - Vass, E.

AU - Martinek, T.

AU - Fülöp, F.

PY - 2009/10/19

Y1 - 2009/10/19

N2 - Stable foldamers in water: Helical peptidic foldamers including H12 and H10/12 helices were constructed and stabilised in water. The foldamers' extra rigidity stems from the strong hydrogen bonding network of the azapeptide groups (see graphic).

AB - Stable foldamers in water: Helical peptidic foldamers including H12 and H10/12 helices were constructed and stabilised in water. The foldamers' extra rigidity stems from the strong hydrogen bonding network of the azapeptide groups (see graphic).

KW - Amino acids

KW - Chirality

KW - Foldamers

KW - Peptides

KW - Peptidomimetics

UR - http://www.scopus.com/inward/record.url?scp=70350215675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350215675&partnerID=8YFLogxK

U2 - 10.1002/chem.200900724

DO - 10.1002/chem.200900724

M3 - Article

C2 - 19746464

AN - SCOPUS:70350215675

VL - 15

SP - 10736

EP - 10741

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 41

ER -