Src and Syk kinases: Key regulators of phagocytic cell activation

Giorgio Berton, Attila Mócsai, Clifford A. Lowell

Research output: Contribution to journalReview article

152 Citations (Scopus)


Src-family kinases and Syk tyrosine kinases have crucial roles in multiple leukocyte intracellular signaling pathways. In immunoreceptor-related pathways, these enzymes work together sequentially, with Src-family kinases phosphorylating specific protein substrates, which in turn recruit and activate Syk. Recent evidence indicates that several non-immunoreceptors also use Src-family kinases and Syk in this same fashion. In leukocyte integrin signaling, the interaction between the kinases is more complex, where they appear to act in a sequential manner but the mechanisms by which they are activated remain poorly defined. Elucidating the regulation of these tyrosine kinase-based signaling pathways in leukocytes remains an important goal in understanding how immune cells respond to the multitude of activating agents they encounter.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
JournalTrends in Immunology
Issue number4
Publication statusPublished - Apr 2005


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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