Src and Syk kinases

Key regulators of phagocytic cell activation

Giorgio Berton, A. Mócsai, Clifford A. Lowell

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

Src-family kinases and Syk tyrosine kinases have crucial roles in multiple leukocyte intracellular signaling pathways. In immunoreceptor-related pathways, these enzymes work together sequentially, with Src-family kinases phosphorylating specific protein substrates, which in turn recruit and activate Syk. Recent evidence indicates that several non-immunoreceptors also use Src-family kinases and Syk in this same fashion. In leukocyte integrin signaling, the interaction between the kinases is more complex, where they appear to act in a sequential manner but the mechanisms by which they are activated remain poorly defined. Elucidating the regulation of these tyrosine kinase-based signaling pathways in leukocytes remains an important goal in understanding how immune cells respond to the multitude of activating agents they encounter.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
JournalTrends in Immunology
Volume26
Issue number4
DOIs
Publication statusPublished - Apr 2005

Fingerprint

src-Family Kinases
Phagocytes
Leukocytes
Protein-Tyrosine Kinases
Integrins
Phosphotransferases
Enzymes
Syk Kinase
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Src and Syk kinases : Key regulators of phagocytic cell activation. / Berton, Giorgio; Mócsai, A.; Lowell, Clifford A.

In: Trends in Immunology, Vol. 26, No. 4, 04.2005, p. 208-214.

Research output: Contribution to journalArticle

Berton, Giorgio ; Mócsai, A. ; Lowell, Clifford A. / Src and Syk kinases : Key regulators of phagocytic cell activation. In: Trends in Immunology. 2005 ; Vol. 26, No. 4. pp. 208-214.
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