Wandering epileptic discharges were induced by topically applied acetylcholine in artificially ventilated rabbits. During focal and spreading seizures the regional cortical blood flow (measured by thermistors) decreased in the discharging area if the frequency of polyspikes surpassed 5 c/sec. These blood flow changes were independent of the alteration of the arterial blood pressure. During "generalizing" and generalized seizures, at onset of synchronous seizure potentials in the 4-5 and 8-9 c/sec frequency ranges, the regional cortical blood flow increased together with the arterial blood pressure. These "pressure-passive" blood flow changes indicate exhaustion of the autoregulation mechanism of cerebral circulation.
|Number of pages||10|
|Journal||Electroencephalography and Clinical Neurophysiology|
|Publication status||Published - Feb 1977|
ASJC Scopus subject areas
- Clinical Neurology