Spreading depression and evoked potentials recorded in the somatosensory cortex of the rat

Gáspár Oláh, Dávid Nagy, Máté Marosi, Tamás Farkas, Zsolt Kis, Árpád Párdutz, János Tajti, László Vécsei, József Toldi

Research output: Contribution to journalArticle

Abstract

Cortical spreading depression (CSD) is associated with changes in the caliber of surface blood vessels; others have described it as a phenomenon which arises spontaneously and repetitively following acute cortical injury in animals, including both focal ischemia and trauma, while yet other researchers consider it to be an electrophysiological substrate of migraine aura, which may trigger headache. Our group is involved in research into both migraine and ischemia-induced pathophysiological states. It therefore appeared reasonable to include the study of CSD in the methodological repertoire utilized in our laboratory. We introduced two models of CSD induction: CSD evoked during continuous topical KCl application and CSD induced through a single KCl microinjection into the cortical tissue. This paper describes details of these two methods and of basic parameters of CSDs.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalActa Biologica Szegediensis
Volume54
Issue number2
Publication statusPublished - Dec 1 2010

Keywords

  • Aura
  • Cortical spreading depression
  • Ischemia
  • Ischemic brain tissue
  • Migraine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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