A sporadikus kromoszómaaberrációk alakulása 1986-2001 között vizsgált egészséges személyek limfocitáiban.

Translated title of the contribution: Sporadic chromosome aberrations in healthy individuals studied between 1986-2001

Zsolt Kelecsényi, Gábor Székely, Sarolta Gundy

Research output: Contribution to journalArticle

Abstract

In the second half of 2002, IARC for Central and Eastern European countries targeted studies on the relationship between chromosomal aberrations (CAs) and cancer risk. For these purposes we preliminarily investigated, under identical methodological circumstances, the base-line level of CAs in peripheral blood lymphocytes of 1414 healthy Hungarian persons between 1986 and 2001. The age and sex as biological, and smoking habit and residency (Budapest, industrial- and agricultural settlements) as environmental confounding factors were evaluated. Previously, people were not exposed to any known potential mutagens. The overall frequencies of aberrant cells (1.60+/-0.05%) were not influenced by sex, age and residency, but the smoking habits (1.84+/-0.09%) had significant impact on the elevation of aberrant cells. Aneuploidy, exchange-type dicentric chromosomes and the total of aberrations increased significantly with the age of the donors. The individual frequency of aberrant cells ranged between 0-12%. No aberrant cells were detected in 35% of individuals, and 1 aberrant cell was found in 23% of the total population, while 42% of the examined persons were characterized with aberrant cell rates between 2-12%. The initial value of 0.85% of aberrant cells doubled by the end of the examined 16-year period, following 2-4-fold fluctuations. None of the investigated biological or environmental factors was responsible for the elevation of the CAs. The causes of the elevation of CA-level can be explained more precisely when these data will be compared to cancer registry database of these persons.

Original languageHungarian
Pages (from-to)169-176
Number of pages8
JournalMagyar Onkologia
Volume47
Issue number2
Publication statusPublished - 2003

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Chromosome Aberrations
Internship and Residency
Habits
Smoking
Mutagens
Aneuploidy
Registries
Neoplasms
Databases
Lymphocytes
Population

ASJC Scopus subject areas

  • Cancer Research

Cite this

A sporadikus kromoszómaaberrációk alakulása 1986-2001 között vizsgált egészséges személyek limfocitáiban. / Kelecsényi, Zsolt; Székely, Gábor; Gundy, Sarolta.

In: Magyar Onkologia, Vol. 47, No. 2, 2003, p. 169-176.

Research output: Contribution to journalArticle

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