Spontaneous myxosarcoma in a cottontail rabbit (Sylvilagus floridanus): Observation of tubular structures in the endoplasmic reticulum of tumor cells

Z. Schaff, P. M. Grimley, H. J. Michelitch, W. G. Banfield

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Abstract

Ultrastructural examination of a spontaneous myxosarcoma in a 6 year old cottontail rabbit (Sylvilagus floridanus) disclosed geometrically packed tubules (250 Å diameter) in the endoplasmic reticulum of >10% of tumor cell sections. The tubules were indistinguishable from structures previously described in virus encephalitis of rabbits and in virus induced neoplasms of other experimental animals. They were also similar in dimensions and location to structures described in the cells of patients with connective tissue diseases. Present observations and review of the literature suggest that the tubular structures appear in two general forms: a tightly packed geometric or 'crystalline' form presently identified and a less compact 'tubuloreticular' form. Although their significance in the endoplasmic reticulum remains obscure, these tubular structures appear to have a limited distribution in mammalian tissues and usually are found in neoplasia or conditions associated with virus infection.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalJournal of the National Cancer Institute
Volume51
Issue number1
Publication statusPublished - 1973

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Myxosarcoma
Endoplasmic Reticulum
Experimental Neoplasms
Encephalitis Viruses
Observation
Rabbits
Satellite Viruses
Connective Tissue Diseases
Virus Diseases
Neoplasms
Viruses

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Spontaneous myxosarcoma in a cottontail rabbit (Sylvilagus floridanus) : Observation of tubular structures in the endoplasmic reticulum of tumor cells. / Schaff, Z.; Grimley, P. M.; Michelitch, H. J.; Banfield, W. G.

In: Journal of the National Cancer Institute, Vol. 51, No. 1, 1973, p. 293-297.

Research output: Contribution to journalArticle

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