Spontaneous migraine attack causes alterations in default mode network connectivity: A resting-state fMRI case report

Andrea Edit Edes, Lajos Rudolf Kozak, Mate Magyar, Terezia Zsombok, Gyongyi Kokonyei, Gyorgy Bagdy, Gabriella Juhasz

Research output: Contribution to journalArticle

5 Citations (Scopus)


Background: Although migraine is one of the most investigated neurologic disorders, we do not have a perfect neuroimaging biomarker for its pathophysiology. One option to improve our knowledge is to study resting-state functional connectivity in and out of headache pain. However, our understanding of the functional connectivity changes during spontaneous migraine attack is partial and incomplete. Case presentation: Using resting-state functional magnetic resonance imaging we assessed a 24-year old woman affected by migraine without aura at two different times: during a spontaneous migraine attack and in interictal phase. Seed-to-voxel whole brain analysis was carried out using the posterior cingulate cortex as a seed, representing the default mode network (DMN). Our results showed decreased intrinsic connectivity within core regions of the DMN with an exception of a subsystem including the dorsal medial and superior frontal gyri, and the mid-temporal gyrus which is responsible for pain interpretation and control. In addition, increased connectivity between the DMN and pain and specific migraine-related areas, such as the pons and hypothalamus, developed during the spontaneous migraine attack. Conclusion: Our preliminary results provide further support for the hypothesis that alterations of the DMN functional connectivity during migraine headache may lead to maladaptive top-down modulation of migraine pain-related areas which might be a specific biomarker for migraine.

Original languageEnglish
Article number165
JournalBMC Research Notes
Issue number1
Publication statusPublished - Apr 26 2017



  • Case report
  • Functional connectivity
  • Headache pain
  • Migraine
  • Migraine attack
  • Neuroimaging
  • Pain processing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this