Inspite of their widespread use the efficacy of β-mimetics is debated in tocolytic therapy. One of the main reasons for this is the receptor desensitization against the β-agonists, a process which decreases their efficacy. We investigated whether this desensitization process also occurs spontaneously during pregnancy. It was found that towards the end of pregnancy contractions stimulated by electric field on isolated rat uterus were inhibited with only a reduced intensity by the β2-agonist terbutaline. In radioliogand binding studies the small density of the β-receptors was shown to decline in their numbers. We conclude that desensitization of the β-receptors occurs even spontaneously in the pregnant rat uterus. This process is assumed to contribute to the human receptor desensitization during tocolytic therapy.
|Number of pages||4|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jan 1 2000|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology