Spontaneous apoptosis and retinoic acid receptor incidence in neuroblastomas and peripheral neuroectodermal tumors

Parvaneh Farid, Mária Babosa, P. Hauser, D. Schuler, B. Szende

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Twelve cases of neuroblastoma (NB) (7 boys and 5 girls) and 4 cases of primitive peripheral neuroectodermal tumor (PNET) (3 boys and 1 girl) were investigated for the presence of apoptosis and retinoic acid receptor (RAR) by immunhistochemical method. The apoptotic index in NB was zero or 1% in 8 children and relatively low (2-4.8%) in the other 4 cases, while it was higher (4.1-10.5 %) in PNET. The RAR index determined by immunoperoxidase reaction in NB was zero or 3% in 5 cases and 9-34% in 7 children. RAR index in PNET was 16-68% in all the 4 cases. Good correlation (r = .47 according to Pearson-Bravis) was found between the number of RAR and spontaneus apoptosis. These results suggest that the PAR index in untreated NB and PNET shows great individual variation since its determination is necessary for the evaluation of the efficacy of retinoic acid treatment.

Original languageEnglish
Pages (from-to)315-321
Number of pages7
JournalPediatric Hematology and Oncology
Volume17
Issue number4
Publication statusPublished - Jun 2000

Fingerprint

Peripheral Primitive Neuroectodermal Tumors
Retinoic Acid Receptors
Cell death
Neuroblastoma
Tumors
Apoptosis
Acids
Incidence
Tretinoin
Tumor

Keywords

  • Apoptosis
  • Neuroblastoma
  • PNET
  • Retinoic acid receptor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology
  • Cancer Research
  • Management of Technology and Innovation

Cite this

Spontaneous apoptosis and retinoic acid receptor incidence in neuroblastomas and peripheral neuroectodermal tumors. / Farid, Parvaneh; Babosa, Mária; Hauser, P.; Schuler, D.; Szende, B.

In: Pediatric Hematology and Oncology, Vol. 17, No. 4, 06.2000, p. 315-321.

Research output: Contribution to journalArticle

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