Heretumoros betegek spontán és citosztatikus kezelést követö kromoszóma aberrációi.

Translated title of the contribution: Spontaneous and cytostatic therapy induced chromosome aberrations in testicular cancer patients

Research output: Contribution to journalArticle

Abstract

Chromosomal aberrations were studied in peripheral blood lymphocytes from only surgery treated testicular cancer patients and treated with chemo- and/or radiotherapy. A distinct increase in spontaneous aberration frequency over the level of 27 healthy controls in 27 patients treated with surgery alone was found. Our data suggest the existence of a certain degree of chromosome instability, which may be a factor to the development of testicular tumour. The frequency of aberrant cells was much higher in 102 treated patients than in the controls. The decrease in aberrant cells was only time-dependently gradual in VPB and X-ray treated patients, while the second line combined treatment modalities caused the highest frequency of aberrant cells in the first two years after the end of courses. The possible relationship between the persistence of chromosomal aberrations and the development of malignancies are discussed in this paper.

Original languageHungarian
Pages (from-to)3141-3146
Number of pages6
JournalOrvosi Hetilap
Volume133
Issue number49
Publication statusPublished - Dec 6 1992

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Testicular Neoplasms
Cytostatic Agents
Chromosome Aberrations
Chromosomal Instability
Therapeutics
Radiotherapy
X-Rays
Lymphocytes
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Heretumoros betegek spontán és citosztatikus kezelést követö kromoszóma aberrációi. / Gundy, S.; Baki, M.; Bodrogi, I.

In: Orvosi Hetilap, Vol. 133, No. 49, 06.12.1992, p. 3141-3146.

Research output: Contribution to journalArticle

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