Spontaneous abortion in multiple pregnancy: Focus on fetal pathology

József Gábor Joó, ákos Csaba, Zsanett Szigeti, J. Rigó

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Multiple pregnancy with its wide array of medical consequences poses an important condition during pregnancy.We performed perinatal autopsy in 49 cases of spontaneous abortion resulting from multiple pregnancies during the study period.Twenty-seven of the 44 twin pregnancies ending in miscarriage were conceived naturally, whereas 17 were conceived through assisted reproductive techniques. Each of the 5 triplet pregnancies ending in miscarriage was conceived through assisted reproductive techniques. There was a positive history of miscarriage in 22.4% of the cases. Monochorial placentation occurred more commonly in multiple pregnancies terminating with miscarriage than in multiple pregnancies without miscarriage. A fetal congenital malformation was found in 8 cases. Three of these cases were conceived through assisted reproductive techniques, and 5 were conceived naturally. Miscarriage was due to intrauterine infection in 36% of the cases.Our study confirms that spontaneous abortion is more common in multiple than in singleton pregnancies. Monochorial placentation predicted a higher fetal morbidity and mortality. In pregnancies where all fetuses were of male gender, miscarriage was more common than in pregnancies where all fetuses were female. Assisted reproductive techniques do not predispose to the development of fetal malformations.

Original languageEnglish
Pages (from-to)458-461
Number of pages4
JournalPathology Research and Practice
Volume208
Issue number8
DOIs
Publication statusPublished - Aug 15 2012

Fingerprint

Multiple Pregnancy
Spontaneous Abortion
Pathology
Assisted Reproductive Techniques
Placentation
Pregnancy
Fetus
Triplet Pregnancy
Fetal Mortality
Twin Pregnancy
Fetal Development
Autopsy
Morbidity

Keywords

  • Developmental disorders
  • Intrauterine infection
  • Monochorionic placentation
  • Multiple pregnancy
  • Perinatal autopsy
  • Spontaneous abortion

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Spontaneous abortion in multiple pregnancy : Focus on fetal pathology. / Joó, József Gábor; Csaba, ákos; Szigeti, Zsanett; Rigó, J.

In: Pathology Research and Practice, Vol. 208, No. 8, 15.08.2012, p. 458-461.

Research output: Contribution to journalArticle

Joó, József Gábor ; Csaba, ákos ; Szigeti, Zsanett ; Rigó, J. / Spontaneous abortion in multiple pregnancy : Focus on fetal pathology. In: Pathology Research and Practice. 2012 ; Vol. 208, No. 8. pp. 458-461.
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