Spleen autotransplantation. Morphological and functional follow-up after spleen autotransplantation in mice: A research summary

Iren Miko, Endre Brath, Norbert Nemeth, Andrea Furka, Sandor Sipka, Katalin Peto, Jozsef Serfozo, Judit Kovacs, Sandor Imre, Ilona Benko, Laszlo Galuska, Sandor Sipka, Geza Acs, Istvan Furka

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In 1986, we started the research on spleen surgery aimed at saving the splenic mass after its traumatic injury, with elaboration of special resection and autotransplantation techniques. The researches started on mongrel dogs and were continued on inbred mice and beagle dogs with complex histological, imaging, and laboratory investigations, following-up the function and the regeneration of autotransplanted spleen chips. Performing research on mice provided more immunological methods, such as lymphocyte subsets, immunoglobulin levels, and monitoring the phagocytic functions. Researches showed evidence also on the presence of apoptosis, furthermore, stem cell studies on regeneration and functional restoration of the spleen chips are in progress. Our results contributed to two multidisciplinary guidelines in Hungary: (1) One of them is under preparation and underlines the importance of spleen saving methods after traumatic splenic injury; (2) The second guideline shows that hemorheological changes can be early indicators of the increased sensitivity to postsplenectomy infections.

Original languageEnglish
Pages (from-to)312-316
Number of pages5
JournalMicrosurgery
Volume27
Issue number4
DOIs
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Surgery

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