The spleen is an important organ with complex functions such as filtration, immunology, storage and hemopoiesis, as main roles. Decrease or loss of splenic function (because of various origins, such atraumatic injury) may lead to serious complications, including sepsis and thromboembolism complications, like the situation after splenectomy. Thus, if possible, the spleen should be salvaged using spleenpreserving surgical techniques. One of these methods is the spleen autotransplantation, by placing "spleen chips" between two layers of greater omentum. 25-year research work on large and small laboratory animal models in our department provided useful data for the clinical practice. The spleen autotransplantation technique could be performed in mice with microsurgical method, creating omental pockets for thin spleen segments. Because of the clinical importance of possible postsplenectomy complications, this novel model can be important for related researches and be suitable for immunological studies. In this chapter the murine model is described, by reviewing the history of its development, and with summarizing the main results and applications related both to experimental and clinical research.
|Title of host publication||Experimental Organ Transplantation|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||13|
|Publication status||Published - Dec 1 2013|
- Novel microsurgical model
- Spleen autotransplantation
ASJC Scopus subject areas