Spire and Cordon-bleu: multifunctional regulators of actin dynamics

Louis Renault, Beáta Bugyi, Marie France Carlier

Research output: Contribution to journalReview article

61 Citations (Scopus)


WASP-homology 2 (WH2) domains, which were first identified in the WASP/Scar (suppressor of cAMP receptor)/WAVE (WASP-family verprolin homologous protein) family of proteins, are multifunctional regulators of actin assembly. Two recently discovered actin-binding proteins, Spire and Cordon-bleu (Cobl), which have roles in axis patterning in developmental processes, use repeats of WH2 domains to generate a large repertoire of novel regulatory activities, including G-actin sequestration, actin-filament nucleation, filament severing and barbed-end dynamics regulation. We describe how these multiple functions selectively operate in a cellular context to control the dynamics of the actin cytoskeleton. In vivo, Spire and Cobl can synergize with other actin regulators. As an example, we outline potential methods to gain insight into the functional basis for reported genetic interactions among Spire, profilin and formin.

Original languageEnglish
Pages (from-to)494-504
Number of pages11
JournalTrends in Cell Biology
Issue number10
Publication statusPublished - Oct 1 2008

ASJC Scopus subject areas

  • Cell Biology

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