Abstract
The spiral ganglion cells provide the afferent innervation of the hair cells of the organ of Corti. Ninety-five percent of these cells (termed type I spiral ganglion neurones) are in synaptic contact with the inner hair cells, whereas about 5% of them are type II cells, which are responsible for the sensory innervation of the outer hair cells. To understand the function of the spiral ganglion neurones, it is important to explore their membrane properties, understand their activity patterns and describe the variety of ionic channels determining their behaviour. In this review, a brief description is given of the various experimental methods that allow the investigation of the spiral ganglion cells, followed by the discussion of their action potential firing patterns and ionic conductances. The presence, distribution and significance of the K+ currents of the spiral ganglion cells are specifically addressed, along with the introduction of the putative subunit compositions of the relevant voltage-gated K+ channels.
| Original language | English |
|---|---|
| Pages (from-to) | 1303-1325 |
| Number of pages | 23 |
| Journal | Pflugers Archiv European Journal of Physiology |
| Volume | 457 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Apr 2009 |
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Keywords
- Action potentials
- Kv subunits
- Spiral ganglion
- Type I cells
- Type II cells
ASJC Scopus subject areas
- Physiology
- Clinical Biochemistry
- Physiology (medical)
Cite this
Spiral ganglion neurones : An overview of morphology, firing behaviour, ionic channels and function. / Rusznák, Zoltán; Szücs, G.
In: Pflugers Archiv European Journal of Physiology, Vol. 457, No. 6, 04.2009, p. 1303-1325.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spiral ganglion neurones
T2 - An overview of morphology, firing behaviour, ionic channels and function
AU - Rusznák, Zoltán
AU - Szücs, G.
PY - 2009/4
Y1 - 2009/4
N2 - The spiral ganglion cells provide the afferent innervation of the hair cells of the organ of Corti. Ninety-five percent of these cells (termed type I spiral ganglion neurones) are in synaptic contact with the inner hair cells, whereas about 5% of them are type II cells, which are responsible for the sensory innervation of the outer hair cells. To understand the function of the spiral ganglion neurones, it is important to explore their membrane properties, understand their activity patterns and describe the variety of ionic channels determining their behaviour. In this review, a brief description is given of the various experimental methods that allow the investigation of the spiral ganglion cells, followed by the discussion of their action potential firing patterns and ionic conductances. The presence, distribution and significance of the K+ currents of the spiral ganglion cells are specifically addressed, along with the introduction of the putative subunit compositions of the relevant voltage-gated K+ channels.
AB - The spiral ganglion cells provide the afferent innervation of the hair cells of the organ of Corti. Ninety-five percent of these cells (termed type I spiral ganglion neurones) are in synaptic contact with the inner hair cells, whereas about 5% of them are type II cells, which are responsible for the sensory innervation of the outer hair cells. To understand the function of the spiral ganglion neurones, it is important to explore their membrane properties, understand their activity patterns and describe the variety of ionic channels determining their behaviour. In this review, a brief description is given of the various experimental methods that allow the investigation of the spiral ganglion cells, followed by the discussion of their action potential firing patterns and ionic conductances. The presence, distribution and significance of the K+ currents of the spiral ganglion cells are specifically addressed, along with the introduction of the putative subunit compositions of the relevant voltage-gated K+ channels.
KW - Action potentials
KW - Kv subunits
KW - Spiral ganglion
KW - Type I cells
KW - Type II cells
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UR - http://www.scopus.com/inward/citedby.url?scp=62549149097&partnerID=8YFLogxK
U2 - 10.1007/s00424-008-0586-2
DO - 10.1007/s00424-008-0586-2
M3 - Article
C2 - 18777041
AN - SCOPUS:62549149097
VL - 457
SP - 1303
EP - 1325
JO - Pflugers Archiv European Journal of Physiology
JF - Pflugers Archiv European Journal of Physiology
SN - 0031-6768
IS - 6
ER -