Spiegelmers as potential receptors for cTnI diagnostics

Zsuzsanna Szeitner, Anna Doleschall, Marina Varga, Katalin Keltai, Katalin Révész, R. Gyurcsányi, T. Mészáros

Research output: Contribution to journalArticle

Abstract

We demonstrate the first application of a nuclease resistant aptamer, the so-called Spiegelmer, in a sandwich-type affinity assay by quantitative assessment of cardiac Troponin I (cTnI) in blood serum samples. To this end, we used a bead-based homogenous proximity assay (AlphaLISA) in which luminescence is generated by the Spiegelmer and antibody-modified donor and acceptor beads brought into proximity by their binding to cTnI.

Original languageEnglish
Pages (from-to)5091-5093
Number of pages3
JournalAnalytical Methods
Volume9
Issue number35
DOIs
Publication statusPublished - Sep 21 2017

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Troponin I
Assays
Antibodies
Luminescence
Blood

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemical Engineering(all)
  • Engineering(all)

Cite this

Szeitner, Z., Doleschall, A., Varga, M., Keltai, K., Révész, K., Gyurcsányi, R., & Mészáros, T. (2017). Spiegelmers as potential receptors for cTnI diagnostics. Analytical Methods, 9(35), 5091-5093. https://doi.org/10.1039/c7ay01777d

Spiegelmers as potential receptors for cTnI diagnostics. / Szeitner, Zsuzsanna; Doleschall, Anna; Varga, Marina; Keltai, Katalin; Révész, Katalin; Gyurcsányi, R.; Mészáros, T.

In: Analytical Methods, Vol. 9, No. 35, 21.09.2017, p. 5091-5093.

Research output: Contribution to journalArticle

Szeitner, Z, Doleschall, A, Varga, M, Keltai, K, Révész, K, Gyurcsányi, R & Mészáros, T 2017, 'Spiegelmers as potential receptors for cTnI diagnostics', Analytical Methods, vol. 9, no. 35, pp. 5091-5093. https://doi.org/10.1039/c7ay01777d
Szeitner Z, Doleschall A, Varga M, Keltai K, Révész K, Gyurcsányi R et al. Spiegelmers as potential receptors for cTnI diagnostics. Analytical Methods. 2017 Sep 21;9(35):5091-5093. https://doi.org/10.1039/c7ay01777d
Szeitner, Zsuzsanna ; Doleschall, Anna ; Varga, Marina ; Keltai, Katalin ; Révész, Katalin ; Gyurcsányi, R. ; Mészáros, T. / Spiegelmers as potential receptors for cTnI diagnostics. In: Analytical Methods. 2017 ; Vol. 9, No. 35. pp. 5091-5093.
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