Speech activation of language dominant hemisphere: A single-photon emission computed tomography study

Katalin Borbély, Albert Gjedde, I. Nyáry, S. Czirják, Nándor Donauer, Alfred Buck

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We tested the prediction that single photon emission computed tomography (SPECT) of the blood flow distribution in speech-activated brain identifies the language-dominant hemisphere. We based the prediction on the hypothesis that language activation leads to focally increased regional cerebral blood flow (rCBF), which is reflected in the uptake of a flow tracer recorded by SPECT. We compared the results of speech activation to the results of functional transcranial Doppler (fTCD) monitoring in the same subjects. Preoperatively, 17 patients (10 women and 7 men with a mean age of 36 ± 15 years) with diagnoses of epilepsy (n = 14) or arteriovenous malformation (AVM) (n = 3) had two SPECT and two stereo-TCD monitoring studies in each case, one at rest, and one during 3 min of speech activation. Except for two left-handed patients with right-hemisphere dominance, the subjects had the highest changes of rCBF from baseline to activation in the left posterior inferior frontal cortex and in contralateral cerebellum. The results show that changes of the level of neuronal activity reflected by the measurement of rCBF variations might be detected by SPECT. Additionally, the evaluation of hemispheric language dominance based on SPECT showed a complete agreement with the evaluation based on fTCD results (yielding a kappa coefficient equal to 1), and therefore, speech-activation SPECT mapping might be helpful in the evaluation of hemispheric language dominance, especially when fMRI and PET are not available or they are contraindicated for some reason.

Original languageEnglish
Pages (from-to)987-994
Number of pages8
JournalNeuroImage
Volume20
Issue number2
DOIs
Publication statusPublished - Oct 1 2003

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Single-Photon Emission-Computed Tomography
Cerebrovascular Circulation
Language
Regional Blood Flow
Arteriovenous Malformations
Patient Rights
Frontal Lobe
Cerebellum
Epilepsy
Magnetic Resonance Imaging
Brain

Keywords

  • Hemispheric language dominance
  • rCBF SPECT
  • Speech activation

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Speech activation of language dominant hemisphere : A single-photon emission computed tomography study. / Borbély, Katalin; Gjedde, Albert; Nyáry, I.; Czirják, S.; Donauer, Nándor; Buck, Alfred.

In: NeuroImage, Vol. 20, No. 2, 01.10.2003, p. 987-994.

Research output: Contribution to journalArticle

Borbély, Katalin ; Gjedde, Albert ; Nyáry, I. ; Czirják, S. ; Donauer, Nándor ; Buck, Alfred. / Speech activation of language dominant hemisphere : A single-photon emission computed tomography study. In: NeuroImage. 2003 ; Vol. 20, No. 2. pp. 987-994.
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