Spectrum of neurodevelopmental disabilities: A cohort study in hungary

Gyurgyinka Gergev, Adrienn Máté, Alíz Zimmermann, Ferenc Rárosi, L. Sztriha

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The spectrum of neurodevelopmental disabilities was studied in a cohort of patients in Hungary. A search for etiologies and assessment of the degree of intellectual disability were carried out. The study included 241 (131 boys) patients. Disability occurred without any prenatal, perinatal, and/or neonatal adverse events in 167 patients. They were classified into the following subgroups: genetic syndromes with recognized etiology, global developmental delay/intellectual disability in association with dysmorphic features but unknown etiology, global developmental delay/intellectual disability without dysmorphic features and recognized etiology, brain malformations, inborn errors of metabolism, leukoencephalopathies, epileptic syndromes, developmental language impairment, and neuromuscular disorders. Adverse events occurred in 74 children classified into subgroups such as cerebral palsy after delivery preterm or at term, and disabilities without cerebral palsy. The etiology was identified in 66.4%, and genetic diagnosis was found in 19.5%. Classification of neurodevelopmental disorders contribute to etiological diagnosis, proper rehabilitation, and genetic counseling.

Original languageEnglish
Pages (from-to)344-356
Number of pages13
JournalJournal of Child Neurology
Volume30
Issue number3
DOIs
Publication statusPublished - Mar 26 2015

Fingerprint

Hungary
Intellectual Disability
Cohort Studies
Cerebral Palsy
Inborn Metabolic Brain Diseases
Leukoencephalopathies
Genetic Counseling
Language
Rehabilitation

Keywords

  • genetic syndromes
  • global developmental delay
  • intellectual disability
  • single domain developmental delay

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Spectrum of neurodevelopmental disabilities : A cohort study in hungary. / Gergev, Gyurgyinka; Máté, Adrienn; Zimmermann, Alíz; Rárosi, Ferenc; Sztriha, L.

In: Journal of Child Neurology, Vol. 30, No. 3, 26.03.2015, p. 344-356.

Research output: Contribution to journalArticle

Gergev, Gyurgyinka ; Máté, Adrienn ; Zimmermann, Alíz ; Rárosi, Ferenc ; Sztriha, L. / Spectrum of neurodevelopmental disabilities : A cohort study in hungary. In: Journal of Child Neurology. 2015 ; Vol. 30, No. 3. pp. 344-356.
@article{b4309f8103f84e81ad1971d6306e9f67,
title = "Spectrum of neurodevelopmental disabilities: A cohort study in hungary",
abstract = "The spectrum of neurodevelopmental disabilities was studied in a cohort of patients in Hungary. A search for etiologies and assessment of the degree of intellectual disability were carried out. The study included 241 (131 boys) patients. Disability occurred without any prenatal, perinatal, and/or neonatal adverse events in 167 patients. They were classified into the following subgroups: genetic syndromes with recognized etiology, global developmental delay/intellectual disability in association with dysmorphic features but unknown etiology, global developmental delay/intellectual disability without dysmorphic features and recognized etiology, brain malformations, inborn errors of metabolism, leukoencephalopathies, epileptic syndromes, developmental language impairment, and neuromuscular disorders. Adverse events occurred in 74 children classified into subgroups such as cerebral palsy after delivery preterm or at term, and disabilities without cerebral palsy. The etiology was identified in 66.4{\%}, and genetic diagnosis was found in 19.5{\%}. Classification of neurodevelopmental disorders contribute to etiological diagnosis, proper rehabilitation, and genetic counseling.",
keywords = "genetic syndromes, global developmental delay, intellectual disability, single domain developmental delay",
author = "Gyurgyinka Gergev and Adrienn M{\'a}t{\'e} and Al{\'i}z Zimmermann and Ferenc R{\'a}rosi and L. Sztriha",
year = "2015",
month = "3",
day = "26",
doi = "10.1177/0883073814532543",
language = "English",
volume = "30",
pages = "344--356",
journal = "Journal of Child Neurology",
issn = "0883-0738",
publisher = "SAGE Publications Inc.",
number = "3",

}

TY - JOUR

T1 - Spectrum of neurodevelopmental disabilities

T2 - A cohort study in hungary

AU - Gergev, Gyurgyinka

AU - Máté, Adrienn

AU - Zimmermann, Alíz

AU - Rárosi, Ferenc

AU - Sztriha, L.

PY - 2015/3/26

Y1 - 2015/3/26

N2 - The spectrum of neurodevelopmental disabilities was studied in a cohort of patients in Hungary. A search for etiologies and assessment of the degree of intellectual disability were carried out. The study included 241 (131 boys) patients. Disability occurred without any prenatal, perinatal, and/or neonatal adverse events in 167 patients. They were classified into the following subgroups: genetic syndromes with recognized etiology, global developmental delay/intellectual disability in association with dysmorphic features but unknown etiology, global developmental delay/intellectual disability without dysmorphic features and recognized etiology, brain malformations, inborn errors of metabolism, leukoencephalopathies, epileptic syndromes, developmental language impairment, and neuromuscular disorders. Adverse events occurred in 74 children classified into subgroups such as cerebral palsy after delivery preterm or at term, and disabilities without cerebral palsy. The etiology was identified in 66.4%, and genetic diagnosis was found in 19.5%. Classification of neurodevelopmental disorders contribute to etiological diagnosis, proper rehabilitation, and genetic counseling.

AB - The spectrum of neurodevelopmental disabilities was studied in a cohort of patients in Hungary. A search for etiologies and assessment of the degree of intellectual disability were carried out. The study included 241 (131 boys) patients. Disability occurred without any prenatal, perinatal, and/or neonatal adverse events in 167 patients. They were classified into the following subgroups: genetic syndromes with recognized etiology, global developmental delay/intellectual disability in association with dysmorphic features but unknown etiology, global developmental delay/intellectual disability without dysmorphic features and recognized etiology, brain malformations, inborn errors of metabolism, leukoencephalopathies, epileptic syndromes, developmental language impairment, and neuromuscular disorders. Adverse events occurred in 74 children classified into subgroups such as cerebral palsy after delivery preterm or at term, and disabilities without cerebral palsy. The etiology was identified in 66.4%, and genetic diagnosis was found in 19.5%. Classification of neurodevelopmental disorders contribute to etiological diagnosis, proper rehabilitation, and genetic counseling.

KW - genetic syndromes

KW - global developmental delay

KW - intellectual disability

KW - single domain developmental delay

UR - http://www.scopus.com/inward/record.url?scp=84923330986&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923330986&partnerID=8YFLogxK

U2 - 10.1177/0883073814532543

DO - 10.1177/0883073814532543

M3 - Article

C2 - 24868008

AN - SCOPUS:84923330986

VL - 30

SP - 344

EP - 356

JO - Journal of Child Neurology

JF - Journal of Child Neurology

SN - 0883-0738

IS - 3

ER -