Spectrum and antibiotic resistance of uropathogens between 2004 and 2015 in a tertiary care hospital in Hungary

András Magyar, Béla Köves, Károly Nagy, András Dobák, Vinodh Kumar Adithyaa Arthanareeswaran, Péter Bálint, Florian Wagenlehner, P. Tenke

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose. Surveillance of the bacterial spectrum and antibiotic-resistance patterns of locally occurring uropathogens is essential to serve as a basis for empirical treatment of urinary tract infections (UTIs), as antibiotic-resistance rates may vary geographically with significant differences between countries and regions, and with time. Methodology. We retrospectively analysed all urine samples taken in the department of urology in a tertiary care hospital in Hungary from January 2004 to December 2015. Results/Key findings. The five most commonly occurring bacteria were Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus mirabilis. Resistance of Escherichia coli to ciprofloxacin increased significantly from 19 to 25 %. Although the resistance of Escherichia coli against cephalosporins showed an increasing trend, it still remained generally low. However, resistance rates of K. pneumoniae to cephalosporins were very high, reaching 60 %, due to the high rate of extended-spectrum-β-lactamase-positive Klebsiella strains. We observed a significant increase in the rate of carbapenem-resistant Pseudomonas aeruginosa. Conclusion. Fluoroquinolones cannot be recommended for empirical treatment in our region. Cephalosporins can be a good empirical choice for treating Gram-negative UTIs, but should be avoided when multi-drug resistant (MDR) bacteria are suspected. Increases in the rate of carbapenem-resistant Pseudomonas aeruginosa, and in the general rate of MDR bacteria, are both a very alarming trend. We recommend practising prudent antibiotic policy, preferably using antibiotics with the narrowest possible spectrum.

Original languageEnglish
Article number000498
Pages (from-to)788-797
Number of pages10
JournalJournal of Medical Microbiology
Volume66
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

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Hungary
Tertiary Healthcare
Cephalosporins
Microbial Drug Resistance
Tertiary Care Centers
Pseudomonas aeruginosa
Carbapenems
Klebsiella pneumoniae
Escherichia coli
Bacteria
Urinary Tract Infections
Bacterial Drug Resistance
Anti-Bacterial Agents
Proteus mirabilis
Klebsiella
Enterococcus faecalis
Fluoroquinolones
Urology
Ciprofloxacin
Pharmaceutical Preparations

Keywords

  • Antibiotic resistance
  • Bacterial spectrum
  • Uropathogens

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Spectrum and antibiotic resistance of uropathogens between 2004 and 2015 in a tertiary care hospital in Hungary. / Magyar, András; Köves, Béla; Nagy, Károly; Dobák, András; Arthanareeswaran, Vinodh Kumar Adithyaa; Bálint, Péter; Wagenlehner, Florian; Tenke, P.

In: Journal of Medical Microbiology, Vol. 66, No. 6, 000498, 01.06.2017, p. 788-797.

Research output: Contribution to journalArticle

Magyar, A, Köves, B, Nagy, K, Dobák, A, Arthanareeswaran, VKA, Bálint, P, Wagenlehner, F & Tenke, P 2017, 'Spectrum and antibiotic resistance of uropathogens between 2004 and 2015 in a tertiary care hospital in Hungary', Journal of Medical Microbiology, vol. 66, no. 6, 000498, pp. 788-797. https://doi.org/10.1099/jmm.0.000498
Magyar, András ; Köves, Béla ; Nagy, Károly ; Dobák, András ; Arthanareeswaran, Vinodh Kumar Adithyaa ; Bálint, Péter ; Wagenlehner, Florian ; Tenke, P. / Spectrum and antibiotic resistance of uropathogens between 2004 and 2015 in a tertiary care hospital in Hungary. In: Journal of Medical Microbiology. 2017 ; Vol. 66, No. 6. pp. 788-797.
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