Specific repression of transthyretin gene expression in rat liver by a peroxisome proliferator clofibrate

Kiyoto Motojima, Sataro Goto, Tsuneo Imanaka

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The effect of clofibrate, a hypolipidemic drug and a potent peroxisome proliferator, on expression of a nonperoxisomal transthyretin (prealbumin) gene was studied using rats fed clofibrate for various periods. Upon feeding a diet containing clofibrate, the level of transthyretin mRNA was down-regulated, reaching 20% of the control level, in an almost reciprocal time course to that of increases in the levels of peroxisomal mRNAs. Studies on expression of other steroid hormone regulated genes suggest that clofibrate may down-regulate several but not all types of steroid hormone regulated mRNA expression.

Original languageEnglish
Pages (from-to)799-806
Number of pages8
JournalBiochemical and biophysical research communications
Volume188
Issue number2
DOIs
Publication statusPublished - Oct 30 1992

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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