Species specificity of thrombin-induced changes in vascular tone

Debebe Gebremedhin, György Ballagi-Pordány, Pál Hadházy, K. Magyar, R. Machovich

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We studied the effects of acetylcholine and human thrombin on the tone of rabbit and dog isolated femoral arteries and aortas with intact endothelium. Acetylcholine (10-9-10-6 mol/l) produced relaxation in the vessels from both species whereas thrombin (10-9-3 × 10-8 mol/l) relaxed only canine arterial smooth muscle. Thrombin pretreatment increased significantly the relaxant potency of acetylcholine in femoral arteries of dogs. The results suggest an interspecies difference in the thrombin-induced endothelium-dependent vasorelaxation.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalEuropean Journal of Pharmacology
Volume132
Issue number1
DOIs
Publication statusPublished - Dec 2 1986

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Species Specificity
Thrombin
Blood Vessels
Acetylcholine
Femoral Artery
Endothelium
Dogs
Vasodilation
Smooth Muscle
Aorta
Canidae
Rabbits

Keywords

  • Acetylcholine
  • Arterial tone
  • Thrombin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Species specificity of thrombin-induced changes in vascular tone. / Gebremedhin, Debebe; Ballagi-Pordány, György; Hadházy, Pál; Magyar, K.; Machovich, R.

In: European Journal of Pharmacology, Vol. 132, No. 1, 02.12.1986, p. 71-74.

Research output: Contribution to journalArticle

Gebremedhin, Debebe ; Ballagi-Pordány, György ; Hadházy, Pál ; Magyar, K. ; Machovich, R. / Species specificity of thrombin-induced changes in vascular tone. In: European Journal of Pharmacology. 1986 ; Vol. 132, No. 1. pp. 71-74.
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