Species-Specific Thiol-Disulfide Equilibrium Constant: A Tool to Characterize Redox Transitions of Biological Importance

Arash Mirzahosseini, Máté Somlyay, Béla Noszál

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Microscopic redox equilibrium constants, a new species-specific type of physicochemical parameters, were introduced and determined to quantify thiol-disulfide equilibria of biological significance. The thiol-disulfide redox equilibria of glutathione with cysteamine, cysteine, and homocysteine were approached from both sides, and the equilibrium mixtures were analyzed by quantitative NMR methods to characterize the highly composite, co-dependent acid-base and redox equilibria. The directly obtained, pH-dependent, conditional constants were then decomposed by a new evaluation method, resulting in pH-independent, microscopic redox equilibrium constants for the first time. The 80 different, microscopic redox equilibrium constant values show close correlation with the respective thiolate basicities and provide sound means for the development of potent agents against oxidative stress.

Original languageEnglish
Pages (from-to)10191-10197
Number of pages7
JournalJournal of Physical Chemistry B
Volume119
Issue number32
DOIs
Publication statusPublished - Aug 13 2015

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

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