Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran

Gyöngyi Szigeti, Ebrahim Sedaghati, Ali Zarei Mahmoudabadi, Ali Naseri, S. Kocsubé, C. Vágvölgyi, J. Varga

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Black aspergilli are among the main causative agents of otomycosis worldwide. In this study, the species assignment of black aspergilli isolated from otomycosis cases in Iran was carried out using sequence analysis of part of the calmodulin gene. The results indicate that Aspergillus niger is not the only black Aspergillus species involved in otomycosis cases in Iran: Aspergillus awamori and Aspergillus tubingensis are also able to cause ear infections. Antifungal susceptibility tests were carried out against five antifungal drugs including amphotericin B, fluconazole, itraconazole, ketoconazole and terbinafine. All isolates were highly susceptible to terbinafine, while they exhibited moderate susceptibilities against amphotericin B, fluconazole and ketoconazole. Aspergillus niger and A. awamori were found to have higher minimal inhibitory concentrations for azoles than A. tubingensis, in accordance with previous findings.

Original languageEnglish
Pages (from-to)333-338
Number of pages6
JournalMycoses
Volume55
Issue number4
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Otomycosis
Aspergillus
Iran
terbinafine
Ketoconazole
Aspergillus niger
Fluconazole
Amphotericin B
Azoles
Itraconazole
Calmodulin
Ear
Sequence Analysis
Infection
Pharmaceutical Preparations
Genes

Keywords

  • Antifungal agents
  • Aspergillus niger
  • Iran
  • Molecular typing
  • Otomycosis

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran. / Szigeti, Gyöngyi; Sedaghati, Ebrahim; Mahmoudabadi, Ali Zarei; Naseri, Ali; Kocsubé, S.; Vágvölgyi, C.; Varga, J.

In: Mycoses, Vol. 55, No. 4, 07.2012, p. 333-338.

Research output: Contribution to journalArticle

Szigeti, Gyöngyi ; Sedaghati, Ebrahim ; Mahmoudabadi, Ali Zarei ; Naseri, Ali ; Kocsubé, S. ; Vágvölgyi, C. ; Varga, J. / Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran. In: Mycoses. 2012 ; Vol. 55, No. 4. pp. 333-338.
@article{2f9c7dc3d5fc45198f385f2ffd20dcaf,
title = "Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran",
abstract = "Black aspergilli are among the main causative agents of otomycosis worldwide. In this study, the species assignment of black aspergilli isolated from otomycosis cases in Iran was carried out using sequence analysis of part of the calmodulin gene. The results indicate that Aspergillus niger is not the only black Aspergillus species involved in otomycosis cases in Iran: Aspergillus awamori and Aspergillus tubingensis are also able to cause ear infections. Antifungal susceptibility tests were carried out against five antifungal drugs including amphotericin B, fluconazole, itraconazole, ketoconazole and terbinafine. All isolates were highly susceptible to terbinafine, while they exhibited moderate susceptibilities against amphotericin B, fluconazole and ketoconazole. Aspergillus niger and A. awamori were found to have higher minimal inhibitory concentrations for azoles than A. tubingensis, in accordance with previous findings.",
keywords = "Antifungal agents, Aspergillus niger, Iran, Molecular typing, Otomycosis",
author = "Gy{\"o}ngyi Szigeti and Ebrahim Sedaghati and Mahmoudabadi, {Ali Zarei} and Ali Naseri and S. Kocsub{\'e} and C. V{\'a}gv{\"o}lgyi and J. Varga",
year = "2012",
month = "7",
doi = "10.1111/j.1439-0507.2011.02103.x",
language = "English",
volume = "55",
pages = "333--338",
journal = "Mycoses",
issn = "0933-7407",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran

AU - Szigeti, Gyöngyi

AU - Sedaghati, Ebrahim

AU - Mahmoudabadi, Ali Zarei

AU - Naseri, Ali

AU - Kocsubé, S.

AU - Vágvölgyi, C.

AU - Varga, J.

PY - 2012/7

Y1 - 2012/7

N2 - Black aspergilli are among the main causative agents of otomycosis worldwide. In this study, the species assignment of black aspergilli isolated from otomycosis cases in Iran was carried out using sequence analysis of part of the calmodulin gene. The results indicate that Aspergillus niger is not the only black Aspergillus species involved in otomycosis cases in Iran: Aspergillus awamori and Aspergillus tubingensis are also able to cause ear infections. Antifungal susceptibility tests were carried out against five antifungal drugs including amphotericin B, fluconazole, itraconazole, ketoconazole and terbinafine. All isolates were highly susceptible to terbinafine, while they exhibited moderate susceptibilities against amphotericin B, fluconazole and ketoconazole. Aspergillus niger and A. awamori were found to have higher minimal inhibitory concentrations for azoles than A. tubingensis, in accordance with previous findings.

AB - Black aspergilli are among the main causative agents of otomycosis worldwide. In this study, the species assignment of black aspergilli isolated from otomycosis cases in Iran was carried out using sequence analysis of part of the calmodulin gene. The results indicate that Aspergillus niger is not the only black Aspergillus species involved in otomycosis cases in Iran: Aspergillus awamori and Aspergillus tubingensis are also able to cause ear infections. Antifungal susceptibility tests were carried out against five antifungal drugs including amphotericin B, fluconazole, itraconazole, ketoconazole and terbinafine. All isolates were highly susceptible to terbinafine, while they exhibited moderate susceptibilities against amphotericin B, fluconazole and ketoconazole. Aspergillus niger and A. awamori were found to have higher minimal inhibitory concentrations for azoles than A. tubingensis, in accordance with previous findings.

KW - Antifungal agents

KW - Aspergillus niger

KW - Iran

KW - Molecular typing

KW - Otomycosis

UR - http://www.scopus.com/inward/record.url?scp=84862248161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862248161&partnerID=8YFLogxK

U2 - 10.1111/j.1439-0507.2011.02103.x

DO - 10.1111/j.1439-0507.2011.02103.x

M3 - Article

C2 - 21895787

AN - SCOPUS:84862248161

VL - 55

SP - 333

EP - 338

JO - Mycoses

JF - Mycoses

SN - 0933-7407

IS - 4

ER -